Academic Journal
Multistep Microwave-Assisted Synthesis of Avobenzone
| العنوان: | Multistep Microwave-Assisted Synthesis of Avobenzone |
|---|---|
| اللغة: | English |
| المؤلفون: | Jordan, Annalisa M., Wilke, Ashley E., Nguyen, Tanifa L., Capistrant, Katelyn C., Zarbock, Katie R., Batiste Simms, Morgan E., Winsor, Brandi R., Wollack, James W. (ORCID |
| المصدر: | Journal of Chemical Education. Mar 2022 99(3):1435-1440. |
| الاتاحة: | Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc |
| Peer Reviewed: | Y |
| Page Count: | 6 |
| تاريخ النشر: | 2022 |
| نوع الوثيقة: | Journal Articles Reports - Evaluative |
| Education Level: | Higher Education Postsecondary Education |
| Descriptors: | Organic Chemistry, Science Instruction, Laboratory Experiments, Hands on Science, Radiation, College Science, Science Experiments |
| DOI: | 10.1021/acs.jchemed.1c00818 |
| تدمد: | 0021-9584 |
| مستخلص: | Multistep synthesis is a key capstone experience in organic laboratory instruction. Here, a four-step synthesis of avobenzone, an active component in sunscreens, has been developed that can be completed in two 4 h laboratory periods. This synthesis incorporates green principles and includes an aldol condensation, electrophilic addition of bromine to an alkene, an E2 dehalogenation of a dibromide, and hydration of an alkyne. Highlights of this synthesis include the use of coupling constants to identify alkene configuration, NMR analysis to determine preferred tautomeric form, the use of microwave irradiation to reduce reaction times, a solvent-free synthesis of a chalcone, and a three-step reaction that can be completed in a single lab period. |
| Abstractor: | As Provided |
| Entry Date: | 2022 |
| رقم الانضمام: | EJ1328598 |
| قاعدة البيانات: | ERIC |
| تدمد: | 0021-9584 |
|---|---|
| DOI: | 10.1021/acs.jchemed.1c00818 |