Academic Journal
Homology Modeling and Molecular Docking for the Science Curriculum
| العنوان: | Homology Modeling and Molecular Docking for the Science Curriculum |
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| اللغة: | English |
| المؤلفون: | McDougal, Owen M., Cornia, Nic, Sambasivarao, S. V. |
| المصدر: | Biochemistry and Molecular Biology Education. Mar-Apr 2014 42(2):179-182. |
| الاتاحة: | Wiley-Blackwell. 350 Main Street, Malden, MA 02148. Tel: 800-835-6770; Tel: 781-388-8598; Fax: 781-388-8232; e-mail: cs-journals@wiley.com; Web site: http://www.wiley.com/WileyCDA |
| Peer Reviewed: | Y |
| Page Count: | 4 |
| تاريخ النشر: | 2014 |
| Intended Audience: | Teachers |
| نوع الوثيقة: | Journal Articles Reports - Descriptive |
| Education Level: | Higher Education Postsecondary Education |
| Descriptors: | Science Instruction, Computer Software, Educational Technology, Computer Uses in Education, Molecular Biology, College Science, Undergraduate Study, Scientific Concepts, Science Experiments, Molecular Structure, Science Process Skills, Biochemistry |
| DOI: | 10.1002/bmb.20767 |
| تدمد: | 1470-8175 |
| مستخلص: | DockoMatic 2.0 is a powerful open source software program (downloadable from sourceforge.net) that allows users to utilize a readily accessible computational tool to explore biomolecules and their interactions. This manuscript describes a practical tutorial for use in the undergraduate curriculum that introduces students to macromolecular structure creation, ligand binding calculations, and visualization of docking results. A student procedure is provided that illustrates the use of DockoMatic to create a homology model for the amino propeptide region (223 amino acids with two disulfide bonds) of collagen a1 (XI), followed by molecular docking of the commercial drug Arixtra® to the homology model of a1 (XI), and finally, analysis of the results of the docking experiment. The activities and Supporting Information described are intended to educate students in the use of computational tools to create and investigate homology models for other systems of interest and to train students to perform and analyze molecular docking studies. The tutorial also serves as a foundation for investigators seeking to explore the viability of using computational biochemistry to study their receptor-ligand binding motifs. |
| Abstractor: | As Provided |
| Entry Date: | 2014 |
| رقم الانضمام: | EJ1028977 |
| قاعدة البيانات: | ERIC |
Full Text Finder | تدمد: | 1470-8175 |
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| DOI: | 10.1002/bmb.20767 |