التفاصيل البيبلوغرافية
| العنوان: |
New immunotherapeutic strategies in acute leukemia |
| المؤلفون: |
Tirado Cabrera, Néstor |
| المساهمون: |
University/Department: Universitat de Barcelona. Facultat de Medicina i Ciències de la Salut |
| Thesis Advisors: |
Menéndez Buján, Pablo, Sánchez Martínez, Diego, Agell i Jané, Neus |
| المصدر: |
TDX (Tesis Doctorals en Xarxa) |
| بيانات النشر: |
Universitat de Barcelona, 2024. |
| سنة النشر: |
2024 |
| وصف مادي: |
176 p. |
| مصطلحات موضوعية: |
Immunologia, Inmunología, Immunology, Immunoteràpia, Inmunoterapia, Immunotheraphy, Hematologia, Hematología, Hematology, Leucèmia aguda, Leucemia aguda, Acute leukemia, Ciències de la Salut |
| Time: |
616.1 |
| الوصف: |
Programa de Doctorat en Biomedicina / Tesi realitzada a la Institut de Recerca Josep Carreras |
| Description (Translated): |
[eng] AIMS: The general aim of this doctoral thesis is to improve current CAR-T immunotherapeutic strategies in the treatment of acute leukemias. The specific aims of this doctoral thesis are: 1. To develop and characterize CD123-directed CAR-DOT cells as an allogeneic-safe, off-the-shelf therapy far the treatment of R/R AML. 2. To engineer CD1axCD3 BiTE-secreting STAb-T cells and compare their effectiveness against conventional CD1a-directed CAR-T cells against coT-ALL. 3. To generate a CCR9-directed immunotherapy far the safe treatment of R/R T-ALL. (i) To validate CCR9 as an immunotherapeutic target far T-ALL. (ii) To generate CCR9-directed CAR-T cells. (iii) To generate dual CCR9/CD1 a-directed CAR |
| نوع الوثيقة: |
Dissertation/Thesis |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| URL الوصول: |
http://hdl.handle.net/10803/692700 |
| Rights: |
L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc-sa/4.0/ |
| رقم الانضمام: |
edstdx.10803.692700 |
| قاعدة البيانات: |
TDX |