التفاصيل البيبلوغرافية
| العنوان: |
Interferon (IFN)-gamma-inducible protein-10: association with histological results, viral kinetics, and outcome during treatment with pegylated IFN-alpha 2a and ribavirin for chronic hepatitis C virus infection |
| المؤلفون: |
Romero, Ana, 1975, Lagging, Martin, 1965, Westin, Johan, 1965, Dhillon, Amar P, Dustin, Lynn B, Pawlotsky, Jean-Michel, Neumann, Avidan U, Ferrari, Carlo, Missale, Gabriele, Haagmans, Bart L, Schalm, Solko W, Zeuzem, Stefan, Negro, Francesco, Verheij-Hart, Elke, Hellstrand, Kristoffer, 1956 |
| المصدر: |
J Infect Dis. 194(7):895-903 |
| مصطلحات موضوعية: |
Medical and Health Sciences, Medicin och hälsovetenskap, Adult, Antiviral Agents/ therapeutic use, Chemokines, CXC/ blood, Drug Therapy, Combination, Female, Hepacivirus/drug effects/ physiology, Hepatitis C, Chronic/ drug therapy/virology, Humans, Interferon Alfa-2a/therapeutic use, Interferon Type II/ pharmacology, Liver/pathology, Male, Middle Aged, Polyethylene Glycols/therapeutic use, RNA, Viral/blood, Ribavirin/therapeutic use, Treatment Outcome, Viral Load |
| الوصف: |
BACKGROUND: We investigated associations between interferon (IFN)-gamma-inducible protein (IP)-10 and liver histological results, viral kinetic response, and treatment outcome in patients infected with hepatitis C virus (HCV) genotypes 1-4. METHODS: Plasma IP-10 was monitored before, during, and after treatment with pegylated IFN- alpha 2a and ribavirin in 265 HCV-infected patients. RESULTS: In univariate analyses, a low baseline IP-10 level was significantly associated with low baseline viral load, rapid viral response (RVR), a sustained viral response (SVR), body mass index <25 kg/m2, and less-pronounced fibrosis, inflammation, and steatosis (for HCV genotypes other than 3). When the results of the univariate analyses were included in multivariate analyses, a low plasma IP-10 level, low baseline viral load, and genotype 2 or 3 infection were independent predictors of an RVR and SVR. IP-10 levels decreased 6 weeks into treatment and remained low in patients with an SVR. By contrast, plasma levels of IP-10 rebounded in patients who had detectable HCV RNA after the completion of treatment. Using cutoff IP-10 levels of 150 and 600 pg/mL for predicting an SVR in patients infected with HCV genotype 1 yielded a specificity and sensitivity of 81% and 95%, respectively. CONCLUSION: Baseline IP-10 levels are predictive of the response to HCV treatment. |
| URL الوصول: |
https://gup.ub.gu.se/publication/55074 |
| قاعدة البيانات: |
SwePub |