Lung function and onset of cardiometabolic diseases in the longitudinal Burden of Obstructive Lung Disease study
| العنوان: | Lung function and onset of cardiometabolic diseases in the longitudinal Burden of Obstructive Lung Disease study |
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| المؤلفون: | Janson, Christer, Potts, James, Malinovschi, Andrei, 1978, Agarwal, Dhiraj, Ahmed, Rana, Aquart-Stewart, Althea, Harrabi, Imed, Denguezli, Meriam, Devereux, Graham, Erhabor, Gregory E, Gislason, Thorarinn, Jogi, Rain, Juvekar, Sanjay K, Knox-Brown, Ben, Koul, Parvaiz, Mortimer, Kevin, Nafees, Asaad Ahmed, Nielsen, Rune, Mahesh, Padukudru Anand, Paraguas, Stefanni Nonna M, Rotevatn, Anders Ørskov, Sooronbaev, Talant, Burney, Peter G J, Amaral, Andre F S |
| المصدر: | BMJ Open Respiratory Research. 12(1) |
| مصطلحات موضوعية: | COPD epidemiology, Clinical Epidemiology, Lung Physiology |
| الوصف: | INTRODUCTION: Previous population-based studies, mainly from high-income countries, have shown that a higher forced vital capacity (FVC) is associated with a lower risk of developing cardiometabolic diseases. The aim of this study was to assess the longitudinal association between spirometry measures and the onset of cardiometabolic diseases across sites in low-income, middle-income and high-income countries.METHODS: The study population comprised 5916 individuals from 15 countries participating in the Burden of Obstructive Lung Disease baseline and follow-up assessments. Postbronchodilator forced expiratory volume in 1 s (FEV1), FVC and FEV1/FVC were measured at baseline. Participants who reported having doctor-diagnosed hypertension, diabetes, heart disease and stroke at follow-up but not at baseline were considered new cases of these diseases. The association between lung function and the onset of participant-reported cardiometabolic diseases was assessed in each site using regression models, and estimates were combined using random effects meta-analysis. Models were adjusted for sex, age, smoking, body mass index and educational level.RESULTS: Participants with greater per cent predicted FVC were less likely to have new-onset diabetes (OR per 10%=0.91, 95% CI 0.84 to 0.99), heart disease (OR per 10%=0.86, 95% CI 0.80 to 0.92) and stroke (OR per 10%=0.81, 95% CI 0.73 to 0.89) during the follow-up period (mean±SD 9.5±3.6 years). A greater percentage of FEV1 was associated with a lower risk of onset of heart disease and stroke. No significant association was found between FEV1/FVC and onset of reported cardiometabolic diseases, except for a higher risk of diabetes (OR per 10%=1.21, 95% CI 1.08 to 1.35) in participants with higher FEV1/FVC.CONCLUSIONS: The findings of this study suggest that a low FVC is more important than a low FEV1/FVC as a risk factor for developing cardiometabolic diseases. The value of including FVC in risk score models to improve their precision in predicting the onset of cardiometabolic diseases should be explored. |
| وصف الملف: | electronic |
| URL الوصول: | https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-548709 https://doi.org/10.1136/bmjresp-2024-002442 https://uu.diva-portal.org/smash/get/diva2:1931993/FULLTEXT01.pdf |
| قاعدة البيانات: | SwePub |
| تدمد: | 20524439 |
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| DOI: | 10.1136/bmjresp-2024-002442 |