Integrated modeling of biomarkers, survival and safety in clinical oncology drug development
| العنوان: | Integrated modeling of biomarkers, survival and safety in clinical oncology drug development |
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| المؤلفون: | Liu, Han, Ibrahim, Eman I.K., Centanni, Maddalena, Sarr, Céline, Venkatakrishnan, Karthik, Friberg, Lena E. |
| المصدر: | Advanced Drug Delivery Reviews. 216 |
| مصطلحات موضوعية: | Anticancer drugs, Pharmacokinetic, Pharmacodynamic, Pharmacometrics, Joint models, Model-informed drug developmen, t Dose optimization, Dose individualization, Tumor growth inhibition model |
| الوصف: | Model-based approaches, including population pharmacokinetic-pharmacodynamic modeling, have become an essential component in the clinical phases of oncology drug development. Over the past two decades, models have evolved to describe the temporal dynamics of biomarkers and tumor size, treatment-related adverse events, and their links to survival. Integrated models, defined here as models that incorporate at least two pharmacodynamic/ outcome variables, are applied to answer drug development questions through simulations, e.g., to support the exploration of alternative dosing strategies and study designs in subgroups of patients or other tumor indications. It is expected that these pharmacometric approaches will be expanded as regulatory authorities place further emphasis on early and individualized dosage optimization and inclusive patient-focused development strategies. This review provides an overview of integrated models in the literature, examples of the considerations that need to be made when applying these advanced pharmacometric approaches, and an outlook on the expected further expansion of model-informed drug development of anticancer drugs.Keywords: Anticancer drugs; Dose individualization; Dose optimization; Joint models; Model-informed drug development; Pharmacodynamic; Pharmacokinetic; Pharmacometrics; Tumor growth inhibition model. |
| وصف الملف: | electronic |
| URL الوصول: | https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-545150 https://doi.org/10.1016/j.addr.2024.115476 https://uu.diva-portal.org/smash/get/diva2:1920671/FULLTEXT01.pdf |
| قاعدة البيانات: | SwePub |
| DOI: | 10.1016/j.addr.2024.115476 |
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