Concentric Needle Jitter in 97 Myasthenia Gravis Patients
| العنوان: | Concentric Needle Jitter in 97 Myasthenia Gravis Patients |
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| المؤلفون: | Kouyoumdjian, Joao Aris, Paiva, Gabriel Pina, Stålberg, Erik |
| المصدر: | Frontiers in Neurology. 11 |
| مصطلحات موضوعية: | jitter, single-fiber electromyography, myasthenia gravis, concentric needle electrode, electrical activation |
| الوصف: | Objectives: To estimate the jitter parameters (single-fiber electromyography) in myasthenia gravis patients mostly by electrical activation in Frontalis, Orbicularis Oculi, and Extensor Digitorum muscles using a concentric needle electrode.Methods: Between 2009 and 2019, a total of 97 myasthenia gravis patients, 52 male, and mean age 54 years were included.Results: Any abnormal jitter parameter in individual muscles was 90.5% (Frontalis), 88.5% (Orbicularis Oculi), and 86.6% (Extensor Digitorum). Any jitter parameter combining Orbicularis Oculi and Frontalis muscle was abnormal in 100% for the ocular, and in 92.9% for the generalized myasthenia gravis. The most abnormal muscle was Orbicularis Oculi for the generalized, and Frontalis for the ocular myasthenia gravis. The decrement was abnormal in 78.4%, 85.9% for the generalized, and 25% for the ocular myasthenia gravis. The mean jitter ranged from 14.2 to 86 mu s (mean 33.3 mu s) for the ocular myasthenia gravis and from 14.4 to 220.4 mu s (mean 66.3 mu s) for the generalized myasthenia gravis. The antibody titers tested positive in 86.6%, 91.8% for the generalized, and 50% for the ocular myasthenia gravis. Thymectomy was done in 48.5%, thymoma was found in 19.6%, and myasthenic crisis occurred by 21.6%.Conclusion: The jitter parameters achieved a 100% abnormality in ocular myasthenia gravis if both the Orbicularis Oculi and Frontalis muscles were tested. There was a high jitter abnormality in generalized myasthenia gravis cases with one muscle tested, with about a 2% increase in sensitivity when a second is added. Concentric needle electrode jitter had high sensitivity similar to the single fiber electrode (93.8%), followed by antibody titers (86.6%), and abnormal decrement (78.4%). |
| وصف الملف: | electronic |
| URL الوصول: | https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-428046 https://doi.org/10.3389/fneur.2020.600680 https://uu.diva-portal.org/smash/get/diva2:1509613/FULLTEXT01.pdf |
| قاعدة البيانات: | SwePub |
| تدمد: | 16642295 |
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| DOI: | 10.3389/fneur.2020.600680 |