التفاصيل البيبلوغرافية
| العنوان: |
Sustained remission in multiple sclerosis after hematopoietic stem cell transplantation |
| المؤلفون: |
Tolf, Andreas, Fagius, Jan, Carlson, Kristina, Åkerfeldt, Torbjörn, Granberg, Tobias, Larsson, Elna-Marie, Burman, Joachim, 1974 |
| المصدر: |
Acta Neurologica Scandinavica. 140(5):320-327 |
| مصطلحات موضوعية: |
cerebrospinal fluid, hematopoietic stem cell transplantation, magnetic resonance imaging, multiple sclerosis |
| الوصف: |
Objectives: To determine whether treatment with autologous hematopoietic stem cell transplantation (HSCT) can induce sustained complete remission in patients with multiple sclerosis (MS).Material and methods: Case series of patients with relapsing‐remitting MS (n = 10) treated at a single center between 2004 and 2007 and followed up for 10 years. The patients were treated with a BEAM/ATG conditioning regimen (n = 9) or a cyclophosphamide/ATG conditioning regimen (n = 1) followed by infusion of unmanipulated autologous hematopoietic stem cells. The primary endpoint was sustained complete remission. Sustained complete remission was defined as “no evidence of disease activity‐4,” sustained for a period of at least 5 years without any ongoing disease‐modifying treatment. Furthermore, MS was considered as “resolved” if intrathecal IgG production and cerebrospinal fluid neurofilament light levels were normalized as well.Results: Five out of 10 patients were in sustained complete remission at the end of the study. In three of them, MS was resolved.Conclusions: Our data demonstrate that sustained complete remission after autologous HSCT for MS is possible. |
| وصف الملف: |
print |
| URL الوصول: |
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-390961 |
| قاعدة البيانات: |
SwePub |