التفاصيل البيبلوغرافية
| العنوان: |
Inflammasomes of the intestinal epithelium |
| المؤلفون: |
Sellin, Mikael E., Maslowski, Kendle M., Maloy, Kevin J., Wolf-Dietrich, Hardt |
| المصدر: |
Trends in immunology. 36(8):442-450 |
| الوصف: |
While the functional importance of inflammasomes in blood-derived cell types is well established, it remains poorly understood how inflammasomes in nonhematopoietic cells contribute to mucosal immunity. Recent studies have revealed functional roles of inflammasomes - particularly NAIP/NLRC4, NLRP6, and noncanonical caspase-4 (caspase-11) - within epithelial cells of the gut in mucosal immune defense, inflammation, and tumorigenesis. Here, we review and discuss these findings in the broader context of tissue compartment-specific mucosal immunity. We propose several models whereby activities of the intestinal epithelial inflammasomes converge on mechanisms to remove compromised epithelial cells, maintain host-microbiota mutualism, and communicate with immune cells of the underlying lamina propria. |
| وصف الملف: |
print |
| URL الوصول: |
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-309864 |
| قاعدة البيانات: |
SwePub |