التفاصيل البيبلوغرافية
| العنوان: |
Use of perfluoro groups in nucleophilic 18F-fluorination |
| المؤلفون: |
Blom, Elisabeth, Karimi, Farhad, Långström, Bengt |
| المصدر: |
Journal of labelled compounds & radiopharmaceuticals. 53(1):24-30 |
| مصطلحات موضوعية: |
perfluoro, nucleophilic 18F-fluorination, F-SPE, chemical reactivity, purification, NATURAL SCIENCES, Chemistry, NATURVETENSKAP, Kemi |
| الوصف: |
Substrates with leaving groups that contained perfluoro moieties were investigated in labelling chemistry in order to exploit their properties to improve reactivity and purification. [F-18] (Fluoromethyl) benzene was used as the model target compound. Precursors containing perfluoroalkyl and perfluoroaryl sulfonate moieties were subjected to nucleophilic F-18-fluorination, and the impact of perfluoro groups on the substitution reaction and product purification was investigated. [F-18]Fluoride interacted with perfluoroalkyl chains, precluding nucleophilic substitution. When perfluoroaryl groups were used, the substitution proceeded, and the separation of product was explored. The radiolabelled product was obtained in 32% analytical yield and the radiochemical purity was increased to approximately 77% using fluorous solid phase extraction purification. |
| وصف الملف: |
print |
| URL الوصول: |
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-108587 |
| قاعدة البيانات: |
SwePub |