التفاصيل البيبلوغرافية
| العنوان: |
Pro-Inflammatory S100A9 Protein Aggregation Promoted by NCAM1 Peptide Constructs |
| المؤلفون: |
Pansieri, Jonathan, Ostojic, Lucija, Iashchishyn, Igor, Magzoub, Mazin, Wallin, Cecilia, Warmlander, Sebastian K. T. S., Graslund, Astrid, Ngoc, Mai Nguyen, Smirnovas, Vytautas, Svedruzic, Zeljko, Morozova-Roche, Ludmilla |
| المصدر: |
ACS Chemical Biology. 14(7):1410-1417 |
| الوصف: |
Amyloid cascade and neuroinflammation are hallmarks of neurodegenerative diseases, and pro-inflammatory S100A9 protein is central to both of them. Here, we have shown that NCAM1 peptide constructs carrying polycationic sequences derived from A beta peptide (KKLVFF) and PrP protein (KKRPKP) significantly promote the S100A9 amyloid self-assembly in a concentration-dependent manner by making transient interactions with individual S100A9 molecules, perturbing its native structure and acting as catalysts. Since the individual molecule misfolding is a rate-limiting step in S100A9 amyloid aggregation, the effects of the NCAM1 construct on the native S100A9 are so critical for its amyloid self-assembly. S100A9 rapid self assembly into large aggregated clumps may prevent its amyloid tissue propagation, and by modulating S100A9 aggregation as a part of the amyloid cascade, the whole process may be effectively tuned. |
| وصف الملف: |
print |
| URL الوصول: |
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-162010 |
| قاعدة البيانات: |
SwePub |