Prognostic significance of specific anti-WT1 IgG antibody level in plasma in patients with ovarian carcinoma
| العنوان: | Prognostic significance of specific anti-WT1 IgG antibody level in plasma in patients with ovarian carcinoma |
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| المؤلفون: | Andersson, Charlotta, Oji, Yusuke, Ohlson, Nina, Wang, Sihan, Li, Xingru, Ottander, Ulrika, Lundin, Eva, Sugiyama, Haruo, Li, Aihong |
| المصدر: | Cancer Medicine. 3(4):909-918 |
| مصطلحات موضوعية: | Ovarian carcinoma, prognosis, WT1, WT1 IgG antibody |
| الوصف: | Ovarian carcinoma (OC) has a poor prognosis and lack early effective screening markers. Wilm's tumor gene 1 (WT1) is overexpressed in OCs. Therefore, it is of great interest to investigate whether WT1-specific antibody (Ab) measurements in plasma can serve as a biomarker of anti-OC response, and is of importance in relation to patient prognosis. Peripheral blood samples were obtained from a total of 103 women with ovarian tumors with median being 1 day (range 0-48 days) before operation. WT1 IgG Ab levels were evaluated using enzyme-linked immunosorbent assay (ELISA). Immunohistochemical analysis of WT1 protein expression was performed on OC tissue samples. We found that low-WT1 Ab level in plasma was related to improved survival in patients diagnosed at stages III-IV and grade 3 carcinomas. Positive WT1 protein staining on OC tissue samples had a negative impact on survival in the entire cohort, both overall survival (OS) (P = 0.046) and progression-free survival (PFS) (P = 0.006), but not in the serous OC subtype. Combining WT1 IgG Ab levels and WT1 staining, patients with high-WT1 IgG Ab levels in plasma and positive WT1 protein staining in cancer tissues had shorter survival, with a significant association in PFS (P = 0.016). These results indicated that WT1 Ab measurements in plasma and WT1 staining in tissue specimens could be useful as biomarkers for patient outcome in the high-risk subtypes of OCs for postoperative individualized therapy. |
| وصف الملف: | electronic |
| URL الوصول: | https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100163 https://doi.org/10.1002/cam4.244 https://umu.diva-portal.org/smash/get/diva2:790413/FULLTEXT01.pdf |
| قاعدة البيانات: | SwePub |
| تدمد: | 20457634 |
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| DOI: | 10.1002/cam4.244 |