Cardiometabolic multimorbidity accelerates cognitive decline and dementia progression
| العنوان: | Cardiometabolic multimorbidity accelerates cognitive decline and dementia progression |
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| المؤلفون: | Dove, Abigail, Marseglia, Anna, Shang, Ying, Grande, Giulia, Vetrano, Davide Liborio, Laukka, Erika J., Fratiglioni, Laura, Xu, Weili |
| المصدر: | Alzheimer's & Dementia. 19(3):821-830 |
| مصطلحات موضوعية: | cardiometabolic disease, cognitive decline, cognitive impairment, dementia, heart disease, population-based cohort study, stroke, type 2 diabetes |
| الوصف: | Introduction: Cardiometabolic diseases (CMDs) have been individually associated with adverse cognitive outcomes, but their combined effect has not been investigated.Methods: A total of 2577 dementia-free participants 60 years of age or older were followed for 12 years to observe changes in cognitive function and to detect incident cognitive impairment, no dementia (CIND) and dementia. CMDs (including type 2 diabetes, heart disease, and stroke) were assessed at baseline through medical records and clinical examinations. Cardiometabolic multimorbidity was defined as the presence of two or more CMDs. Data were analyzed using multi-adjusted linear mixed-effects models, Cox regression, and Laplace regression.Results: CMD multimorbidity was associated with cognitive decline, CIND (hazard ratio [HR] 1.73; 95% confidence interval CI 1.23 to 2.44), and its progression to dementia (HR 1.86; 95% CI 1.17 to 2.97). CMD multimorbidity accelerated the onset of CIND by 2.3 years and dementia by 1.8 years.Conclusions: CMD multimorbidity accelerates cognitive decline and increases the risk of both CIND and its conversion to dementia. |
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| URL الوصول: | https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-207351 https://doi.org/10.1002/alz.12708 |
| قاعدة البيانات: | SwePub |
| تدمد: | 15525260 15525279 |
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| DOI: | 10.1002/alz.12708 |