The GRADE Working Group clarifies the construct of certainty of evidence
| العنوان: | The GRADE Working Group clarifies the construct of certainty of evidence |
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| المؤلفون: | Hultcrantz, Monica, Rind, David, Akl, Elie A., Treweek, Shaun, Mustafa, Reem A., Iorio, Alfonso, Alper, Brian S., Meerpohl, Joerg J., Murad, M. Hassan, Ansari, Mohammed T., Katikireddi, Srinivasa Vittal, Östlund, Pernilla, Tranæus, Sofia, Christensen, Robin, Gartlehner, Gerald, Brozek, Jan, Izcovich, Ariel, Schünemann, Holger, Guyatt, Gordon |
| المصدر: | Journal of Clinical Epidemiology. 87:4-13 |
| مصطلحات موضوعية: | GRADE, Certainty of evidence, Thresholds, Guidelines, Systematic reviews, Health technology assessment |
| الوصف: | Objective: To clarify the grading of recommendations assessment, development and evaluation (GRADE) definition of certainty of evidence and suggest possible approaches to rating certainty of the evidence for systematic reviews, health technology assessments, and guidelines. Study Design and Setting: This work was carried out by a project group within the GRADE Working Group, through brainstorming and iterative refinement of ideas, using input from workshops, presentations, and discussions at GRADE Working Group meetings to produce this document, which constitutes official GRADE guidance. Results: Certainty of evidence is best considered as the certainty that a true effect lies on one side of a specified threshold or within a chosen range. We define possible approaches for choosing threshold or range. For guidelines, what we call a fully contextualized approach requires simultaneously considering all critical outcomes and their relative value. Less-contextualized approaches, more appropriate for systematic reviews and health technology assessments, include using specified ranges of magnitude of effect, for example, ranges of what we might consider no effect, trivial, small, moderate, or large effects. Conclusion: It is desirable for systematic review authors, guideline panelists, and health technology assessors to specify the threshold or ranges they are using when rating the certainty in evidence. (C) 2017 The Authors. Published by Elsevier Inc. |
| وصف الملف: | electronic |
| URL الوصول: | https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-6008 https://doi.org/10.1016/j.jclinepi.2017.05.006 https://mau.diva-portal.org/smash/get/diva2:1402896/FULLTEXT01.pdf |
| قاعدة البيانات: | SwePub |
| تدمد: | 08954356 18785921 |
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| DOI: | 10.1016/j.jclinepi.2017.05.006 |