التفاصيل البيبلوغرافية
| العنوان: |
The impact of pre-existing thyroid diseases on susceptibility to respiratory infections or self-reported sickness during the SARS-CoV-2 pandemic |
| المؤلفون: |
Rops, Maartje A. J., Moorlag, Simone J. C. F. M., Deuren, Rosanne C. van, Jaeger, Martin, Joosten, Leo A. B., Medici, Marco, Netea, Mihai G., Smit, Jan W. A., Netea-Maier, Romana T. |
| المصدر: |
Archives of Endocrinology and Metabolism. January 2022 |
| بيانات النشر: |
Sociedade Brasileira de Endocrinologia e Metabologia, 2022. |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Thyroid dysfunction, COVID-19, SARS-CoV-2 |
| الوصف: |
Introduction: This study aimed to evaluate the incidence, severity and presence of symptoms of respiratory tract infections and COVID-19, in patients with pre-existing thyroid dysfunction compared to individuals without thyroid diseases, during the peak month of the COVID-19 pandemic in the Netherlands. Subjects and methods: In this retrospective observational cohort study, all patients currently under follow-up at the Radboud UMC for thyroid dysfunction received a digital questionnaire. Primary outcomes were incidence of self-reported sickness and cases diagnosed with COVID-19. We compared these primary outcomes between these patients and individuals without thyroid diseases that received the same questionnaire, recruited from the Human Functional Genomics Cohort at the Radboud UMC. Results: In total, 238 patients with pre-existing thyroid dysfunction and 161 controls were included. Patients did not report more sickness (30.7% vs. 29.2%; p = 0.752) or microbiologically confirmed SARS-CoV-2 infections (1.7% vs. 0.6%; p = 0.351). COVID-19 clinical diagnosis was more frequently made in patients with thyroid diseases (4.2% vs. 0.6%; p = 0.032), despite overall lower incidence of self-reported respiratory related symptoms (52.8% vs. 63.8%; p = 0.028), compared to controls. Sub-group analysis between patients with autoimmune and not-autoimmune thyroid dysfunction did not reveal significant associations with respect to any of the outcome measures. Conclusion: This retrospective survey of a cohort of patients with from a tertiary academic hospital suggests that pre-existing thyroid dysfunction, independent from the aetiology, does not lead to an apparent risk to develop respiratory tract infections and COVID-19 related symptoms. |
| نوع الوثيقة: |
article |
| وصف الملف: |
text/html |
| اللغة: |
English |
| تدمد: |
2359-3997 |
| DOI: |
10.20945/2359-3997000000436 |
| URL الوصول: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022005007201 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edssci.S2359.39972022005007201 |
| قاعدة البيانات: |
SciELO |
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