التفاصيل البيبلوغرافية
| العنوان: |
Paraoxonase 1 serum activity in women: the effects of menopause, the C(-107)T polymorphism and food intake |
| المؤلفون: |
Ritta, Mauren Castro, Baldez, Aline Marques, Oliveira, Isabel Oliveira de, Garcia, Driele Neske, Souza, Paola Spiering, Andrade, Kelvin Ruan da Silva, Valle, Sandra Costa, Pieniz, Simone, Barros, Carlos Castilho, Masternak, Michal M., Schneider, Augusto |
| المصدر: |
Archives of Endocrinology and Metabolism. June 2019 63(3) |
| بيانات النشر: |
Sociedade Brasileira de Endocrinologia e Metabologia, 2019. |
| سنة النشر: |
2019 |
| مصطلحات موضوعية: |
PON1, aging, HDL, SNPs, nutrigenetics |
| الوصف: |
Objective The aims of this study were to investigate changes in serum paraoxonase 1 (PON1) activity in women at the pre and postmenopausal stages and its association with the PON1 C(-107)T polymorphism and food intake profile. Subjects and methods A cross-sectional study with female patients aged between 35 and 59 years old was conducted. Women were divided into two groups: premenopausal (n = 40) and postmenopausal (n = 36). Women enrolled in the study had serum PON1, total cholesterol, HDL, LDL, glucose and HbA1c, as well as the BMI measured. Additionally, women were genotyped for the PON1 T(-107)C polymorphism and the food intake profile was obtained through interview. Results Glucose (p = 0.03), HbA1c (p = 0.002) and total cholesterol (p = 0.002)concentrations were higher in post than premenopausal women, however PON1 activity was not different (p > 0.05). Carriers of the C allele had higher PON1 activity (CC: 88.9 ± 6.5 U/mL and CT: 79.9 ± 4.7 U/mL) than women of the TT genotype (66.6 ± 5.9 U/mL) (p < 0.05). However, the model predicting PON1 activity was slightly better when genotype, total fat and cholesterol content in the diet were all included. Conclusion In sum, we observed that the PON1 C(-107)T genotype was the major regulator of PON1 activity, and menopause had no effect on PON1 activity. The lipid and glycemic profile were altered in postmenopausal women. |
| نوع الوثيقة: |
article |
| وصف الملف: |
text/html |
| اللغة: |
English |
| تدمد: |
2359-3997 |
| DOI: |
10.20945/2359-3997000000130 |
| URL الوصول: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972019000600272 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edssci.S2359.39972019000600272 |
| قاعدة البيانات: |
SciELO |
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