التفاصيل البيبلوغرافية
| العنوان: |
Endocan (ESM-1) levels in gingival crevicular fluid correlate with ICAM-1 and LFA-1 in periodontitis |
| المؤلفون: |
Tayman, Mahmure Ayşe, Önder, Canan, Kurgan, Şivge, Serdar, Muhittin Abdulkadir, Günhan, Meral |
| المصدر: |
Brazilian Oral Research. January 2021 35 |
| بيانات النشر: |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO, 2021. |
| سنة النشر: |
2021 |
| مصطلحات موضوعية: |
Intercellular Adhesion Molecule-1, Lymphocyte Function-Associated Antigen-1 |
| الوصف: |
Endocan, a 50 kDa soluble proteoglycan, also called endothelial cell-specific molecule-1 (ESM-1), is involved in many major cellular activities and has been reported to be overexpressed in inflammatory conditions. This study aims to determine ESM-1 levels in gingival crevicular fluid (GCF) samples from individuals with periodontitis to determine the correlation between the levels of lymphocyte-function-associated antigen-1 (LFA-1), intercellular adhesion molecule-1 (ICAM-1), and clinical findings of periodontitis. This study enrolled 27 individuals diagnosed with Stage III-Grade C generalized periodontitis and 16 individuals as healthy controls. Bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment loss (CAL) were calculated. Enzyme-linked immunosorbent assay (ELISA) test was used for detecting the levels of ESM-1, ICAM-1, and LFA-1 in GCF samples. PPD, BOP, CAL, and GCF volumes were significantly increased in patients with periodontitis in comparison to the control group (p < 0.001). The total amount of ESM-1, ICAM-1, and LFA-1 levels in GCF were increased in the periodontitis group (p < 0.001). ESM-1 level correlated with PPD, BOP, and CAL (p < 0.05). ICAM-1 level correlated with BOP and CAL (p < 0.05). LFA-1 level correlated with PPD and CAL (p < 0.05). Our data indicate that ESM-1, ICAM-1, and LFA-1 levels are increased in GCF of patients with periodontitis. These molecules could be associated with the pathogenesis and progression of periodontal disease. |
| نوع الوثيقة: |
article |
| وصف الملف: |
text/html |
| اللغة: |
English |
| تدمد: |
1806-8324 |
| DOI: |
10.1590/1807-3107bor-2021.vol35.0005 |
| URL الوصول: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242021000100204 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edssci.S1806.83242021000100204 |
| قاعدة البيانات: |
SciELO |
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