التفاصيل البيبلوغرافية
| العنوان: |
Nanostructured SBA-15 silica as an adjuvant in immunizations with hepatitis B vaccine |
| المؤلفون: |
Scaramuzzi, Karina, Oliveira, Denise Cristina André, Carvalho, Luciana Vieira, Tambourgi, Denise Vilarinho, Tenório, Elisabeth Christina Nunes, Rizzi, Marisa, Mussalem, Juliana, Fantini, Márcia Carvalho de Abreu, Botosso, Viviane Fongaro, Sant´Anna, Osvaldo Augusto |
| المصدر: |
einstein (São Paulo). December 2011 9(4) |
| بيانات النشر: |
Instituto Israelita de Ensino e Pesquisa Albert Einstein, 2011. |
| سنة النشر: |
2011 |
| مصطلحات موضوعية: |
Hepatitis B, Oral vaccination, Adjuvants, Immunological memory |
| الوصف: |
Objective: To evaluate the applicability of SBA-15 silica as an adjuvant in immunizations with purified particles of the viral protein HBsAg, the main component of hepatitis B vaccine, Butang®, produced by Instituto Butantan. Methods: BALB/c mice orally or subcutaneously received 0.5 μg of HBsAg adsorbed/encapsulated to SBA-15 or adsorbed to Al(OH)3. To assess the secondary immune response, a subcutaneous booster was administered 30 days after the first immunization. Individual serum and fecal samples of each group were periodically collected for specific antibody titration by ELISA. Results: Analysis of secretory IgA showed that mice orally primed with HBsAg on SBA-15 had increased levels of specific antibodies in primary and secondary immune responses. Specific serum IgA and IgG titers in HBsAg:SBA-15-orally immunized mice reached higher levels after the booster, demonstrating the effectiveness of oral vaccination with the use of silica. All immunized groups showed higher IgG1 levels. Conclusion: Our results clearly indicate the promising use of SBA-15 as an adjuvant, especially in oral immunizations. |
| نوع الوثيقة: |
article |
| وصف الملف: |
text/html |
| اللغة: |
English |
| تدمد: |
1679-4508 |
| DOI: |
10.1590/s1679-45082011ao2162 |
| URL الوصول: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082011000400436 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edssci.S1679.45082011000400436 |
| قاعدة البيانات: |
SciELO |