التفاصيل البيبلوغرافية
| العنوان: |
Recombinogenic activity of Pantoprazole® in somatic cells of Drosophila melanogaster |
| المؤلفون: |
Lopes, Jeyson Césary, Machado, Nayane Moreira, Saturnino, Rosiane Soares, Nepomuceno, Júlio César |
| المصدر: |
Genetics and Molecular Biology. March 2015 38(1) |
| بيانات النشر: |
Sociedade Brasileira de Genética, 2015. |
| سنة النشر: |
2015 |
| مصطلحات موضوعية: |
Drosophila melanogaster, mutagenicity, proton pump inhibitors, Pantoprazole, recombinogenicity, SMART |
| الوصف: |
Pantoprazole® is one of the leading proton pump inhibitors (PPIs) used in the treatment of a variety of diseases related to the upper gastrointestinal tract. However, studies have shown an increased risk of developing gastric cancer, intestinal metaplasia and hyperplasia of endocrine cells with prolonged use. In the present study, the somatic mutation and recombination test (SMART) was employed to determine the mutagenic effects of Pantoprazole on Drosophila melanogaster. Repeated treatments with Pantoprazole were performed on 72-hour larvae of the standard (ST) and high bioactivation (HB) crosses at concentrations of 2.5, 5.0, and 10.0 μM. In addition, doxorubicin (DXR) was administered at 0.4 mM, as a positive control. When administered to ST descendants, total number of spots were statistically significant at 2.5 and 5.0 μM concentrations. For HB descendants, a significant increase in the total number of spots was observed among the marked transheterozygous (MH) flies. Through analysis of balancer heterozygous (BH) descendants, recombinogenic effects were observed at all concentrations in descendants of the HB cross. In view of these experimental conditions and results, it was concluded that Pantoprazole is associated with recombinogenic effects in Drosophila melanogaster. |
| نوع الوثيقة: |
article |
| وصف الملف: |
text/html |
| اللغة: |
English |
| تدمد: |
1415-4757 |
| DOI: |
10.1590/S1415-475738120140154 |
| URL الوصول: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000100101 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edssci.S1415.47572015000100101 |
| قاعدة البيانات: |
SciELO |
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