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Sodium butyrate does not decrease the evolution of precancerous lesions in rats

التفاصيل البيبلوغرافية
العنوان: Sodium butyrate does not decrease the evolution of precancerous lesions in rats
المؤلفون: Silva, Fernanda Guimarães Drummond e, Penido, Luisa Costa Penna, Valente, Flávia Xavier, Mendes, Maria Carolina Santos, Rosa, Damiana Diniz, Glória, Maria Beatriz Abreu, Peluzio, Maria do Carmo Gouveia
المصدر: Acta Cirúrgica Brasileira. December 2010 25(6)
بيانات النشر: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2010.
سنة النشر: 2010
مصطلحات موضوعية: Colonic Neoplasms, Precancerous Conditions, Butyrates, Rats
الوصف: PURPOSE: To evaluate the preventive effect of sodium butyrate in the appearance of aberrant crypt foci (ACF) in rats after induction with the carcinogen 1,2-dimethylhydrazine (DMH). METHODS: Forty Wistar rats were separated into four groups (n=10) distributed as follows: control 1, control 2, butyrate 1 and butyrate 2. The groups control 1 and butyrate 1 remained under experimentation for 4 weeks, while the groups control 2 and butyrate 2 remained for 8 weeks. In the first four weeks, the animals of the control groups received water ad libitum and the animals of the butyrate groups received a sodium butyrate solution (3.4%) ad libitum. Injections of the drug 1,2-dimethylhydrazine were applied during the two first weeks of the experiment in all the animals, concurrently with the application of sodium butyrate. The large intestine of the animals was removed, for the analysis of the ACF and of the content of polyamines. The animal feces were collected for the analysis of the SCFA profile. RESULTS: The spermidine presented a higher concentration in the group butyrate 2 in comparison to the group control 2. There was a significant difference in the concentration value (µmol/mL) of acetate in comparison to the groups control 2 and butyrate 2. CONCLUSION: The use of sodium butyrate together with the induction of colorectal cancer was not effective in the prevention of the disease progression.
نوع الوثيقة: article
وصف الملف: text/html
اللغة: English
تدمد: 0102-8650
DOI: 10.1590/S0102-86502010000600009
URL الوصول: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502010000600009
Rights: info:eu-repo/semantics/openAccess
رقم الانضمام: edssci.S0102.86502010000600009
قاعدة البيانات: SciELO
الوصف
تدمد:01028650
DOI:10.1590/S0102-86502010000600009