التفاصيل البيبلوغرافية
| العنوان: |
An extract of Polygonum multiflorum protects against free radical damage induced by ultraviolet B irradiation of the skin |
| المؤلفون: |
Hwang, I.K., Yoo, K.-Y., Kim, D.W., Jeong, S.J., Won, C.-K., Moon, W.-K., Kim, Y.S., Kwon, D.Y., Won, M.H., Kim, D.-W. |
| المصدر: |
Brazilian Journal of Medical and Biological Research. September 2006 39(9) |
| بيانات النشر: |
Associação Brasileira de Divulgação Científica, 2006. |
| سنة النشر: |
2006 |
| مصطلحات موضوعية: |
Polygonum multiflorum extract, Skin, Ultraviolet B irradiation, Free radicals, Cu,Zn-superoxide dismutase, Hairless mouse |
| الوصف: |
Over the last decades, the incidence of ultraviolet B (UVB)-related skin problems has been increasing. Damages induced by UVB radiation are related to mutations that occur as a result of direct DNA damage and/or the production of reactive oxygen species. We investigated the anti-oxidant effects of a Polygonum multiflorum thumb extract against skin damage induced by UVB irradiation. Female SKH-1 hairless mice were divided into three groups: control (N = 7), distilled water- (N = 10), and P. multiflorum extract-treated (PM, N = 10) groups. The PM (10 g) was extracted with 100 mL distilled water, cryo-dried and 9.8 g was obtained. The animals received a topical application of 500 µL distilled water or PM extract (1, 2, 4, 8, and 16%, w/v, dissolved in distilled water) for 30 min after UVB irradiation (wavelength 280-320 nm, 300 mJ/cm²; 3 min) of the dorsal kin for 14 days, and skin immunohistochemistry and Cu,Zn-superoxide dismutase (SOD1) activity were determined. SOD1 immunoreactivity, its protein levels and activities in the skin were significantly reduced by 70% in the distilled water-treated group after UVB irradiation compared to control. However, in the PM extract-treated groups, SOD1 immunoreactivity and its protein and activity levels increased in a dose-dependent manner (1-16%, w/v, PM extract) compared to the distilled water-treated group. SOD1 protein levels and activities in the groups treated with 8 and 16%, w/v, PM extract recovered to 80-90% of the control group levels after UVB. These results suggest that PM extract strongly inhibits the destruction of SOD1 by UV radiation and probably contains anti-skin photoaging agents. |
| نوع الوثيقة: |
article |
| وصف الملف: |
text/html |
| اللغة: |
English |
| تدمد: |
0100-879X |
| DOI: |
10.1590/S0100-879X2006000900005 |
| URL الوصول: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000900005 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edssci.S0100.879X2006000900005 |
| قاعدة البيانات: |
SciELO |
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