التفاصيل البيبلوغرافية
| العنوان: |
Babesia bovis: expression of adhesion molecules in bovine umbilical endothelial cells stimulated with plasma from infected cattle |
| المؤلفون: |
Vargas, Marlene I., Patarroyo, Joaquín H., Hernandez, Mayra, Peconick, Ana P., Patarroyo, Adriana M., Tafur, Gabriel A., Araújo, Leandro S., Valente, Fabrício |
| المصدر: |
Pesquisa Veterinária Brasileira. October 2014 34(10) |
| بيانات النشر: |
Colégio Brasileiro de Patologia Animal - CBPA, 2014. |
| سنة النشر: |
2014 |
| مصطلحات موضوعية: |
Babesia bovis, physiopathology, adhesion molecules, endothelial cells |
| الوصف: |
Ten male, 12-month-old Jersey with intact spleens, serologically and parasitologically free from Babesia were housed individually in an arthropod-free isolation system from birth and throughout entire experiment. The animals were randomly divided into two groups. Five animals (group A) were intravenously inoculated with 6.6 X10(7) red blood cells parasitized with pathogenic sample of Babesia bovis (passage 7 BboUFV-1), for the subsequent "ex vivo" determination of the expression of adhesion molecules. Five non-inoculated animals (group B) were used as the negative control. The expression of the adhesion molecules ICAM-1, VCAM, PECAM-1 E-selectin and thrombospondin (TSP) was measured in bovine umbilical vein endothelial cells (BUVECs). The endothelial cells stimulated with a pool of plasma from animals infected with the BboUFV-1 7th passage sample had a much more intense immunostaining of ICAM-1, VCAM, PECAM-1 E-selectin and TSP, compared to the cells which did not received the stimulus. The results suggest that proinflammatory cytokines released in the acute phase of babesiosis may be involved in the expression of adhesion molecules thereby implicating them in the pathophysiology of babesiosis caused by B. bovis. |
| نوع الوثيقة: |
article |
| وصف الملف: |
text/html |
| اللغة: |
English |
| تدمد: |
0100-736X |
| DOI: |
10.1590/S0100-736X2014001000002 |
| URL الوصول: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2014001000002 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edssci.S0100.736X2014001000002 |
| قاعدة البيانات: |
SciELO |