التفاصيل البيبلوغرافية
| العنوان: |
CD14 genotype and functional dichotomy of CD14+ and CD14- cells are associated with activated immune response and development of Chagas dilated cardiomyopathy |
| المؤلفون: |
Costa, Germano Carneiro, Rocha, Manoel Otávio da Costa, Souza, Paulo Eduardo Alencar de, Melo, Diego Felipe SA, Moreira, Paula Rocha, Gollob, Kenneth John, Nunes, Maria do Carmo Pereira, Dutra, Walderez Ornelas |
| المصدر: |
Memórias do Instituto Oswaldo Cruz. January 2020 115 |
| بيانات النشر: |
Instituto Oswaldo Cruz, Ministério da Saúde, 2020. |
| سنة النشر: |
2020 |
| مصطلحات موضوعية: |
Chagas cardiomyopathy, CD14, polymorphism |
| الوصف: |
We aimed to investigate the association of CD14 -260C/T (rs2569190) polymorphism and Chagas cardiomyopathy and the functional characteristics of CD14+ and CD14- monocytes upon infection with Trypanosoma cruzi. We observed an association between the T- genotype (absence of allele -260T) related to low CD14 expression and the dilated cardiomyopathy type of Chagas disease. Furthermore, we observed that CD14- monocytes showed a more activated profile upon in vitro infection with T. cruzi than CD14+ monocytes. Our findings suggest that T- genotype is associated with susceptibility to develop Chagas dilated cardiomyopathy, likely linked to the T. cruzi-induced inflammatory profile of CD14- monocytes. |
| نوع الوثيقة: |
other |
| وصف الملف: |
text/html |
| اللغة: |
English |
| تدمد: |
0074-0276 |
| DOI: |
10.1590/0074-02760200110 |
| URL الوصول: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762020000100422 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edssci.S0074.02762020000100422 |
| قاعدة البيانات: |
SciELO |
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