التفاصيل البيبلوغرافية
| العنوان: |
Serum levels of adiponectin, CCL3/MIP-1α, and CCL5/RANTES discriminate migraine from tension-type headache patients |
| المؤلفون: |
Domingues, Renan B., Duarte, Halina, Senne, Carlos, Bruniera, Gustavo, Brunale, Fernando, Rocha, Natália P., Teixeira, Antonio L. |
| المصدر: |
Arquivos de Neuro-Psiquiatria. August 2016 74(8) |
| بيانات النشر: |
Academia Brasileira de Neurologia - ABNEURO, 2016. |
| سنة النشر: |
2016 |
| مصطلحات موضوعية: |
migraine disorders, tension-type headache, adiponectin, chemokines, neurotrophic factors |
| الوصف: |
Objectives Inflammatory molecules and neurotrophic factors are implicated in pain modulation; however, their role in primary headaches is not yet clear. The aim of this study was to compare the levels of serum biomarkers in migraine and tension-type headache. Methods This was a cross-sectional study. We measured serum levels of adiponectin, chemokines, and neurotrophic factors in patients with migraine and tension-type headache. Depression and anxiety symptoms, headache impact and frequency, and allodynia were recorded. Results We included sixty-eight patients with migraine and forty-eight with tension-type headache. Cutaneous allodynia (p = 0.035), CCL3/MIP-1α (p = 0.041), CCL5/RANTES (p = 0.013), and ADP (p = 0.017) were significantly higher in migraine than in tension-type headache. The differences occurred independently of anxiety and depressive symptoms, frequency and impact of headache, and the presence of pain. Conclusions This study showed higher CCL3/MIP-1α, CCL5/RANTES, and ADP levels in migraine in comparison with tension-type headache. Our findings suggest distinctive roles of these molecules in the pathophysiology of these primary headaches. |
| نوع الوثيقة: |
article |
| وصف الملف: |
text/html |
| اللغة: |
English |
| تدمد: |
0004-282X |
| DOI: |
10.1590/0004-282X20160096 |
| URL الوصول: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000800626 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edssci.S0004.282X2016000800626 |
| قاعدة البيانات: |
SciELO |