التفاصيل البيبلوغرافية
| العنوان: |
A study of T CD4, CD8 and B lymphocytes in narcoleptic patients |
| المؤلفون: |
Coelho, Fernando Morgadinho Santos, Pradella-Hallinan, Márcia, Alves, Gabriela Rodrigues, Bittencourt, Lia Rita Azeredo, Pedrazzoli Neto, Mário, Moreira, Fábio, Tufik, Sérgio |
| المصدر: |
Arquivos de Neuro-Psiquiatria. June 2007 65(2b) |
| بيانات النشر: |
Academia Brasileira de Neurologia - ABNEURO, 2007. |
| سنة النشر: |
2007 |
| مصطلحات موضوعية: |
narcolepsy, lymphocytes, immunology, HLA-DQB1*0602 allele |
| الوصف: |
Narcolepsy is characterized by excessive daytime sleep and cataplexy. Little is known about the possible difference in pathophysiology between patients with or without cataplexy. OBJECTIVE: To quantify T CD4, T CD8 and B lymphocytes in subgroups of patients with narcolepsy and the presence or absence of the HLA-DQB1*0602 allele between groups. METHOD: Our study was prospective and controlled (transversal) with 22 narcoleptic patients and 23 health control subjects. Patients underwent an all-night polysomnographic recording (PSG) and a multiple sleep latency Test (MSLT). The histocompatibility antigen allele (HLA-DQB1*0602), T CD4, CD8 and B lymphocytes were quantified in control subjects and in narcoleptics. RESULTS: The HLA-DQB1*0602 allele was identified in 10 (62.5%) of our 16 cataplexic subjects and in 2 (33.3%) of the 6 patients without cataplexy (p=0.24). In control subjects, HLA-DQB1*0602 allele was identified in 5 (20%). A significant decrease in T CD4 and B lymphocytes was found in narcoleptic patients with recurrent cataplexy when compared with our patients without cataplexy. CONCLUSION: Autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis were associated with a decrease in sub-group of T CD4 and B lymphocytes. A drop in B lymphocytes count in reumathoid arthritis might, it is posited, be correlated to the presence of HLA-DRB1 allele along with an overall worsened outcome of the affliction. The theory of an increase in consumption of B lymphocytes over the maturation phase has likewise been put forward. Our study reinforces the view that narcolepsy should be considered from an immunological perspective. |
| نوع الوثيقة: |
article |
| وصف الملف: |
text/html |
| اللغة: |
English |
| تدمد: |
0004-282X |
| DOI: |
10.1590/S0004-282X2007000300011 |
| URL الوصول: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000300011 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edssci.S0004.282X2007000300011 |
| قاعدة البيانات: |
SciELO |