التفاصيل البيبلوغرافية
| العنوان: |
Polymorphism of the estrogen receptor β gene is related to infertility and infertility-associated endometriosis |
| المؤلفون: |
Zulli, Karina, Bianco, Bianca, Mafra, Fernanda Abani, Teles, Juliana Souto, Christofolini, Denise Maria, Barbosa, Caio Parente |
| المصدر: |
Arquivos Brasileiros de Endocrinologia & Metabologia. August 2010 54(6) |
| بيانات النشر: |
Sociedade Brasileira de Endocrinologia e Metabologia, 2010. |
| سنة النشر: |
2010 |
| مصطلحات موضوعية: |
Endometriosis, estrogen receptor β, estrogen, infertility, polymorphism |
| الوصف: |
OBJECTIVE: To determine the frequency of the estrogen receptor b gene (ERβ) +1730 G/A polymorphism in infertile women with and without endometriosis and controls. SUBJECTS AND METHODS: Case-control study that included 136 women with endometriosis, 69 women without endometriosis and 209 fertile women as controls. The ERβ gene + 1730 G/A polymorphism was identified by RFLP-PCR (Restriction Fragment Length Polymorphism - Polymerase Chain Reaction). RESULTS: Genotypes GG, GA and AA of the ERβ gene presented frequencies of 60.3%, 38.2% and 1.5%, respectively, in the women with endometriosis (p < 0.0022). Of the infertile women without endometriosis, 63.8% presented the normal homozygous genotype GG, 30.4% the GA heterozygous genotype, and 5.8% the homozygous mutated genotype AA (p < 0.0275). In the control group, 77.5% presented the normal homozygous genotype GG, 21.1% the heterozygous genotype GA, and 1.4% the homozygous mutated genotype AA. CONCLUSION: The data suggest that the estrogen receptor β gene (ERβ) +1730 G/A polymorphism can be associated with risk of infertility and endometriosis-associated infertility. |
| نوع الوثيقة: |
article |
| وصف الملف: |
text/html |
| اللغة: |
English |
| تدمد: |
0004-2730 |
| DOI: |
10.1590/S0004-27302010000600010 |
| URL الوصول: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302010000600010 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edssci.S0004.27302010000600010 |
| قاعدة البيانات: |
SciELO |