التفاصيل البيبلوغرافية
| العنوان: |
Structure, synthesis of hierridin C and discovery of prevalent alkylresorcinol biosynthesis in picocyanobacteria |
| المؤلفون: |
Costa, Margarida, Sampaio-Dias, I.E., Castelo-Branco, R., Scharfenstein, H., Rezende de Castro, R., Silva, Artur M. S., Schneider, M.P.C., Araújo, Maria João, Martins, Rosário, Domingues, V.F., Nogueira, F., Camões, V., Vasconcelosa, V.M., Leão, P.N. |
| المساهمون: |
Instituto de Higiene e Medicina Tropical (IHMT), Global Health and Tropical Medicine (GHTM), Vector borne diseases and pathogens (VBD), RUN |
| بيانات النشر: |
ChemRxiv, 2018. |
| سنة النشر: |
2018 |
| مصطلحات موضوعية: |
QD Chemistry, QR Microbiology, General Biochemistry,Genetics and Molecular Biology, General Pharmacology, Toxicology and Pharmaceutics, Drug Discovery, SDG 3 - Good Health and Well-being |
| الوصف: |
Small, single-celled planktonic cyanobacteria are ubiquitous in the world’s oceans yet tend not to to be perceived as biosynthetically-prolific organisms. Here we report the isolation and structure elucidation of hierridin C, an antiplasmodial halogenated alkylresorcinol produced in very low amounts by the picocyanobacterium Cyanobiumsp. LEGE 06113. We describe a simple, straightforward synthetic route to the scarcely-produced hierridins that relies on a key, highly regioselective halogenation step. In addition, we show that these compounds originate from a type III PKS pathway and that similar biosynthetic gene clusters are found in a variety of bacterial genomes, most notably those of the globally-distributed picocyanobacteria genera Prochlorococcus, Cyanobiumand Synechococcus. |
| نوع الوثيقة: |
Other |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
PURE: 62517034 |
| DOI: |
10.26434/chemrxiv.7090526.v1 |
| الاتاحة: |
http://hdl.handle.net/10362/157780 |
| Rights: |
open access |
| رقم الانضمام: |
rcaap.com.unl.run.unl.pt.10362.157780 |
| قاعدة البيانات: |
RCAAP |