Academic Journal
Membrane proteins structures: A review on computational modeling tools
| العنوان: | Membrane proteins structures: A review on computational modeling tools |
|---|---|
| المؤلفون: | Almeida, Jose G., Preto, Antonio J., Koukos, Panagiotis I., Bonvin, Alexandre M. J. J., Moreira, Irina S. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Algorithms, Computational Biology, Humans, Membrane Proteins, Molecular Dynamics Simulation, Software |
| الوصف: | Membrane proteins (MPs) play diverse and important functions in living organisms. They constitute 20% to 30% of the known bacterial, archaean and eukaryotic organisms' genomes. In humans, their importance is emphasized as they represent 50% of all known drug targets. Nevertheless, experimental determination of their three-dimensional (3D) structure has proven to be both time consuming and rather expensive, which has led to the development of computational algorithms to complement the available experimental methods and provide valuable insights. |
| نوع الوثيقة: | Journal Article |
| اللغة: | English |
| Relation: | F/00578/2014; MEMBRANEPROT 659826; CENTRO-01-0145-FEDER-000008; TOP-PUNT grant BC.000664.1; https://www.sciencedirect.com/science/article/pii/S000527361730233X?via%3Dihub |
| الاتاحة: | http://hdl.handle.net/10316/48362 |
| Rights: | Embargoed Access URL: http://purl.org/coar/access_right/c_f1cf |
| رقم الانضمام: | rcaap.com.uc.estudogeral.sib.uc.pt.10316.48362 |
| قاعدة البيانات: | RCAAP |
| الوصف غير متاح. |