التفاصيل البيبلوغرافية
| العنوان: |
Genetic variants of CYP2C9 and IL-6 on female infertility |
| المؤلفون: |
Cardoso, R., Gonçalves, A., da Silva, J.M., Oliveira, C., Xavier, P., Alves, H., Barros, A., Botelho, M.C. |
| المساهمون: |
Repositório Científico do Instituto Nacional de Saúde |
| بيانات النشر: |
Instituto Nacional de Saúde Doutor Ricardo Jorge, IP, 2017. |
| سنة النشر: |
2017 |
| مصطلحات موضوعية: |
Genetic Variants, Female Infertility |
| الوصف: |
AIM: To study the polymorphic variants in CYP2C9*2*3 and the C-174G promoter polymorphism of the IL-6 gene on Infertile Women.BACKGROUND: - Infertility affects 15–20% of couples worldwide. Within the past decades, there has been a steady rise in the treatment of female infertility with several drugs; - The cytochrome P450 (CYP) genes are oxygenases involved in estrogen biosynthesis and metabolism, generation of DNA damaging procarcinogens, and response to anti-estrogen therapies used in female infertility treatments: - Interleukin-6 (IL-6) is a pleiotropic proinflammatory cytokine, highly expressed in the female urogenital tract and reproductive organs. It has been implicated in estrogen metabolism imbalance. |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| الاتاحة: |
http://hdl.handle.net/10400.18/4800 |
| Rights: |
open access |
| رقم الانضمام: |
rcaap.com.rinsa.repositorio.insa.pt.10400.18.4800 |
| قاعدة البيانات: |
RCAAP |