Patent
أعرض في EDS

Drug eluting ocular implant and method of treating an ocular disorder

التفاصيل البيبلوغرافية
العنوان: Drug eluting ocular implant and method of treating an ocular disorder
Patent Number: 12201,557
تاريخ النشر: January 21, 2025
Appl. No: 18/060126
Application Filed: November 30, 2022
مستخلص: Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allows for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.
Inventors: Dose Medical Corporation (San Clemente, CA, US)
Assignees: Dose Medical Corporation (Aliso Viejo, CA, US)
Claim: 1. A method of treating an ocular disorder, comprising: inserting an implant into an eye, the implant comprising: an outer shell defining an interior space, the outer shell having a proximal end and a closed distal end; a permeable or semi-permeable membrane positioned at or near the proximal end of the outer shell; a cap comprising an orifice and securing the permeable or semi-permeable membrane to the outer shell of the implant; a retention protrusion extending from the closed distal end; and at least one drug within the interior space, wherein the implant is configured to elute the at least one drug through the orifice of the cap; and anchoring the retention protrusion of the implant to a sclera of the eye.
Claim: 2. The method of claim 1 , wherein anchoring the retention protrusion to the sclera of the eye further comprises positioning the retention protrusion such that it extends into but not through the sclera of the eye.
Claim: 3. The method of claim 1 , wherein the implant is inserted using an applicator comprising a handpiece having an elongate tip connected to a distal end of the handpiece.
Claim: 4. The method of claim 3 , wherein inserting the implant further comprises using an actuator disposed on the handpiece to release the implant from a holder positioned at the distal end of the elongate tip.
Claim: 5. The method of claim 1 , further comprising eluting one or more drugs through the permeable or semi-permeable membrane, wherein the permeable or semi-permeable membrane at least partially controls a rate of elution.
Claim: 6. The method of claim 1 , further comprising advancing the implant through an anterior chamber of the eye towards a trabecular meshwork.
Claim: 7. The method of claim 1 , wherein at least one of the inserting and anchoring is performed using a gonioscope.
Claim: 8. The method of claim 1 , wherein inserting the implant further comprises inserting the implant through an incision made on a temporal side of the eye.
Claim: 9. A method of treating an ocular disorder, comprising: inserting a delivery instrument releasably holding a drug delivery implant into an eye; advancing the delivery instrument through an anterior chamber of the eye towards a trabecular meshwork; anchoring a retention protrusion extending from a distal end of the drug delivery implant to an intraocular tissue, wherein a proximal end of the drug delivery implant comprising an opening configured to elute a drug is positioned within an anterior chamber of the eye, the drug delivery implant comprising a cap comprising an orifice and securing a permeable or semi-permeable membrane to the drug delivery implant, wherein the drug delivery implant is configured to elute the drug through the orifice of the cap; releasing the drug delivery implant from the delivery instrument; and removing the delivery instrument from the eye.
Claim: 10. The method of claim 9 , wherein inserting the delivery instrument further comprises inserting the delivery instrument through an incision made on a temporal side of the eye.
Claim: 11. The method of claim 9 , wherein anchoring the retention protrusion further comprises anchoring the retention protrusion through the trabecular meshwork.
Claim: 12. The method of claim 11 , wherein anchoring the retention protrusion further comprises anchoring the retention protrusion to a sclera.
Claim: 13. The method of claim 9 , wherein an open end of the drug delivery implant is positioned within the anterior chamber of the eye when the retention protrusion is anchored.
Claim: 14. The method of claim 9 , wherein anchoring the retention protrusion further comprises extending the retention protrusion into Schlemm's canal.
Claim: 15. The method of claim 9 , wherein the delivery instrument comprises an elongate tip.
Claim: 16. The method of claim 9 , wherein the permeable or semi-permeable membrane at least partially controls a rate of elution.
Claim: 17. The method of claim 9 , further comprising injecting a viscoelastic into the eye.
Claim: 18. The method of claim 9 , wherein at least one of the inserting, advancing, and anchoring is performed using a gonioscope.
Claim: 19. The method of claim 9 , wherein the drug is travoprost.
Claim: 20. The method of claim 1 , wherein the at least one drug is travoprost.
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Primary Examiner: Prebilic, Paul B
Attorney, Agent or Firm: Knobbe, Martens, Olson & Bear, LLP
رقم الانضمام: edspgr.12201557
قاعدة البيانات: USPTO Patent Grants
الوصف
الوصف غير متاح.