Patent
Atlas registration for resting state network mapping in patients with brain tumors
| العنوان: | Atlas registration for resting state network mapping in patients with brain tumors |
|---|---|
| Patent Number: | 11443,429 |
| تاريخ النشر: | September 13, 2022 |
| Appl. No: | 16/889192 |
| Application Filed: | June 01, 2020 |
| مستخلص: | A method for mapping brain function of a subject includes generating a lesion mask using a search light algorithm based on a plurality of anatomical images of the subject. The plurality of anatomical images are registered with atlas images by nonlinear atlas registration using the generated lesion mask to generate a warping map. A plurality of functional images of the subject are resampled using the warping map to generate a functional map, functional connectivity is computed using the functional map and a multi-layer perceptron. |
| Inventors: | Park, Ki Yun (St. Louis, MO, US); Snyder, Abraham (St. Louis, MO, US); Leuthardt, Eric (St. Louis, MO, US) |
| Assignees: | Washington University (St. Louis, MO, US) |
| Claim: | 1. A method for mapping brain function of a subject, the method comprising: receiving a plurality of functional images of a brain of the subject ascertained during a resting state; receiving a plurality of anatomical images of the brain of the subject; defining one or more regions in the plurality of anatomical images to be excluded from atlas registration of the plurality of anatomical images; registering the plurality of anatomical images with atlas images by nonlinear atlas registration with the defined one or more regions excluded to generate a warping map; registering the plurality of functional images with atlas images using the warping map to guide the registration; and computing functional connectivity of the brain of the subject using the registered functional images. |
| Claim: | 2. The method of claim 1 , further generating a resting state network map of the brain of the subject based on the computed functional connectivity of the brain of the subject. |
| Claim: | 3. The method of claim 2 , wherein generating a resting state network map of the brain of the subject comprises inputting the computed functional connectivity into a neural network trained to estimate class membership for voxels of functional images of the brain to a plurality of resting state networks. |
| Claim: | 4. The method of claim 3 , wherein the neural network comprises a multilayer perceptron. |
| Claim: | 5. The method of claim 1 , wherein the plurality of functional images of a brain of the subject comprises resting state functional magnetic resonance imaging (rs-fMRI) images. |
| Claim: | 6. The method of claim 1 , wherein defining one or more regions to be excluded from atlas registration comprises executing a searchlight algorithm programmed to compare voxels of the plurality of anatomical images to corresponding voxels of a plurality of atlas images. |
| Claim: | 7. The method of claim 6 , wherein the searchlight algorithm is programmed to identify one or more lesions of the brain of the subject based on the comparison of voxels of the plurality of anatomical images to corresponding voxels of the plurality of atlas images and to use the identified lesions as the one or more regions in the plurality of anatomical images to be excluded from atlas registration of the plurality of anatomical images. |
| Claim: | 8. A computing device for use in a system for mapping brain function of a subject, the computing device comprising: a processor; and a memory storing instructions that, when executed by the processor, cause the processor to: receive a plurality of functional images of a brain of the subject ascertained during a resting state; receive a plurality of anatomical images of the brain of the subject; define one or more regions in the plurality of anatomical images to be excluded from atlas registration of the plurality of anatomical images; register the plurality of anatomical images with atlas images by nonlinear atlas registration with the defined one or more regions excluded to generate a warping map; register the plurality of functional images with atlas images using the warping map to guide the registration; and compute functional connectivity of the brain of the subject using the registered functional images. |
| Claim: | 9. The computing device of claim 8 , wherein the memory includes instructions that cause the processor to generate a resting state network map of the brain of the subject based on the computed functional connectivity of the brain of the subject. |
| Claim: | 10. The computing device of claim 9 , wherein the memory includes instructions that cause the processor to generate the resting state network map of the brain of the subject by inputting the computed functional connectivity into a neural network trained to estimate class membership for voxels of functional images of the brain to a plurality of resting state networks. |
| Claim: | 11. The computing device of claim 10 , wherein the neural network comprises a multilayer perceptron. |
| Claim: | 12. The computing device of claim 8 , wherein the plurality of functional images of a brain of the subject comprises resting state functional magnetic resonance imaging (rs-fMRI) images. |
| Claim: | 13. The computing device of claim 8 , wherein the memory includes instructions that cause the processor to define one or more regions to be excluded from atlas registration by executing a searchlight algorithm programmed to compare voxels of the plurality of anatomical images to corresponding voxels of a plurality of atlas images. |
| Claim: | 14. The computing device of claim 13 , wherein the searchlight algorithm is programmed to identify one or more lesions or other abnormalities of the brain of the subject based on the comparison of voxels of the plurality of anatomical images to corresponding voxels of the plurality of atlas images and to use the identified lesions or other abnormalities as the one or more regions in the plurality of anatomical images to be excluded from atlas registration of the plurality of anatomical images. |
| Claim: | 15. A non-transitory computer readable medium comprising instructions that, when executed by at least one processor, cause the processor to: receive a plurality of functional images of a brain of the subject; receive a plurality of anatomical images of the brain of the subject; define one or more regions in the plurality of anatomical images to be excluded from atlas registration of the plurality of anatomical images; register the plurality of anatomical images with atlas images by nonlinear atlas registration with the defined one or more regions excluded to generate a warping map; register the plurality of functional images with atlas images using the warping map to guide the registration; and compute functional connectivity of the brain of the subject using the registered functional images. |
| Claim: | 16. The non-transitory computer readable medium of claim 15 , wherein the instructions further cause the processor to generate a resting state network map of the brain of the subject based on the computed functional connectivity of the brain of the subject. |
| Claim: | 17. The non-transitory computer readable medium of claim 16 , wherein the instructions cause the processor to generate the resting state network map of the brain of the subject by inputting the computed functional connectivity into a neural network trained to estimate class membership for voxels of functional images of the brain to a plurality of resting state networks. |
| Claim: | 18. The non-transitory computer readable medium of claim 17 , wherein the neural network comprises a multilayer perceptron. |
| Claim: | 19. The non-transitory computer readable medium of claim 15 , wherein the instructions cause the processor to define one or more regions to be excluded from atlas registration by executing a searchlight algorithm programmed to compare voxels of the plurality of anatomical images to corresponding voxels of a plurality of atlas images. |
| Claim: | 20. The non-transitory computer readable medium of claim 19 , wherein the searchlight algorithm is programmed to identify one or more lesions or other abnormalities of the brain of the subject based on the comparison of voxels of the plurality of anatomical images to corresponding voxels of the plurality of atlas images and to use the identified lesions or other abnormalities as the one or more regions in the plurality of anatomical images to be excluded from atlas registration of the plurality of anatomical images. |
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| Primary Examiner: | Huynh, Van D |
| Attorney, Agent or Firm: | Armstrong Teasdale LLP |
| رقم الانضمام: | edspgr.11443429 |
| قاعدة البيانات: | USPTO Patent Grants |
| الوصف غير متاح. |