Patent
أعرض في EDS

Gene expression profile as an endometrial receptivity marker

التفاصيل البيبلوغرافية
العنوان: Gene expression profile as an endometrial receptivity marker
Patent Number: 10081,840
تاريخ النشر: September 25, 2018
Appl. No: 13/057135
Application Filed: July 22, 2009
مستخلص: The present invention relates to determining the receptivity of human endometrium from a gene expression profile. More specifically, the invention consists of developing a specific expression microarray of endometrial receptivity (Endometrial Receptivity Array or ERA) which allows evaluating the receptive state of a human endometrium, as well as assessing said state for diagnostic and therapeutic purposes.
Inventors: Simón Vallés, Carlos (Valencia, ES); Horcajadas Almansa, José Antonio (Valencia, ES); Díaz Gimeno, Patricia (Valencia, ES); Pellicer Martínez, Antonio (Valencia, ES)
Assignees: Igenomix S.L. (Paterna (Valencia), ES)
Claim: 1. A method for detecting endometrial receptivity to embryo implantation in a human subject, the method comprising: (a) performing an assay on an endometrial sample from the human subject to determine a gene expression profile of the sample, wherein the gene expression profile comprises the genes listed in FIG. 2 ; (b) determining that the human subject has endometrial receptivity based on a fold change greater than or equal to about three for expression of the genes in the gene expression profile when compared to a non-receptive endometrial sample; and (c) transferring an embryo to the endometrium of the human subject determined to have endometrial receptivity.
Claim: 2. The method of claim 1 , wherein the endometrial sample is obtained from the fundus of the uterus of the human subject.
Claim: 3. The method of claim 1 , wherein the endometrial sample is obtained after an endogenous luteinizing hormone (LH) surge in the human subject.
Claim: 4. The method of claim 1 , wherein the gene expression profile is measured using any of the oligonucleotides set forth as SEQ ID NOs: 1-579 or with any of the oligonucleotides listed in FIG. 4 .
Claim: 5. The method of claim 1 , wherein the gene expression profile is measured using quantitative PCR (qPCR).
Claim: 6. The method of claim 1 , wherein the non-receptive sample is a sample obtained 1, 3, or 5 days after an endogenous luteinizing hormone (LH) surge in the human subject.
Claim: 7. A method for detecting endometrial receptivity to embryo implantation in a human subject, the method comprising: (a) performing an assay on an endometrial sample from the human subject to determine a gene expression profile of the sample, wherein the gene expression profile consists essentially of genes listed in FIG. 2 in an endometrial sample from the human subject; (b) determining that the human subject has endometrial receptivity based on a fold change greater than or equal to about three for expression of the genes in the gene expression profile when compared to a non-receptive endometrial sample; and (c) transferring an embryo to the endometrium of the human subject determined to have endometrial receptivity.
Claim: 8. The method of claim 7 , wherein the endometrial sample is obtained from the fundus of the uterus of the human subject.
Claim: 9. The method of claim 7 , wherein the endometrial sample is obtained after an endogenous luteinizing hormone (LH) surge in the human subject.
Claim: 10. The method of claim 7 , wherein the gene expression profile is measured using any of the oligonucleotides set forth as SEQ ID NOs: 1-579 or with any of the oligonucleotides listed in FIG. 4 .
Claim: 11. The method of claim 7 , wherein the gene expression profile is measured using quantitative PCR (qPCR).
Claim: 12. The method of claim 7 , wherein the non-receptive sample is a sample obtained 1, 3, or 5 days after an endogenous luteinizing hormone (LH) surge in the human subject.
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Primary Examiner: Ault, Addison D
Attorney, Agent or Firm: Wolf, Greenfield & Sacks, P.C.
رقم الانضمام: edspgr.10081840
قاعدة البيانات: USPTO Patent Grants
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