Patent
Hemostatic agent for topical and internal use
| العنوان: | Hemostatic agent for topical and internal use |
|---|---|
| Patent Number: | 8,703,176 |
| تاريخ النشر: | April 22, 2014 |
| Appl. No: | 11/061243 |
| Application Filed: | February 18, 2005 |
| مستخلص: | This invention relates to deployable hemostatic materials comprising chitosan fibers. The hemostatic materials are suitable for use in sealing or controlling active bleeding from artery and vein lacerations and punctures, and for controlling oozing from tissue. |
| Inventors: | Zhu, Yong Hua (Redlands, CA, US); Yang, Chang Zheng (Jiangsu, CN); Kirsch, Wolff M. (Redlands, CA, US) |
| Assignees: | Loma Linda University Medical Center (Loma Linda, CA, US) |
| Claim: | 1. A hemostatic material, the material comprising a nonwoven fabric comprising a plurality of chitosan fiber layers secured to each other to form a net structure by treatment with glacial acetic acid or an acid solution of pH 3.0 to 4.5, wherein the chitosan has a molecular weight of about 1100 kDa or greater, and a degree of deacetylation of about 90% or greater, wherein surfaces of the chitosan fiber layers are further treated by application of glacial acetic acid to form ammonium salt of chitosan. |
| Claim: | 2. The hemostatic material of claim 1 , wherein the nonwoven fabric has a rough side and a smooth side. |
| Claim: | 3. The hemostatic material of claim 1 , wherein the wherein both sides of the nonwoven fabric are rough. |
| Claim: | 4. The hemostatic material of claim 1 , wherein the fabric comprises from 2 to 25 layers. |
| Claim: | 5. A hemostatic suture, the suture comprising chitosan fibers secured to each other by treatment with glacial acetic acid or an acid solution of pH 3.0 to 4.5, wherein the chitosan has a molecular weight of about 1100 kDa or greater, and a degree of deacetylation of about 90% or greater, wherein the chitosan fibers are further treated by application of glacial acetic acid to form ammonium salt of chitosan. |
| Claim: | 6. The hemostatic suture of claim 5 , comprising chitosan fiber filaments twisted together. |
| Claim: | 7. The hemostatic suture of claim 5 , comprising chitosan fiber filaments braided together. |
| Claim: | 8. The hemostatic suture of claim 5 , comprising chitosan fiber filaments spun together. |
| Claim: | 9. The hemostatic material of claim 1 , wherein the chitosan fibers are of uniform thickness. |
| Claim: | 10. The hemostatic material of claim 1 , wherein the chitosan fibers are of a mixture of thicknesses. |
| Claim: | 11. The hemostatic material of claim 1 , wherein the chitosan fibers treated by application of glacial acetic acid are adhered together. |
| Claim: | 12. The hemostatic material of claim 1 , wherein the chitosan fibers treated by application of glacial acetic acid exhibit enhanced hemostatic effect and bioadhesion to wet tissue when compared to untreated chitosan fibers. |
| Claim: | 13. The hemostatic suture of claim 5 , wherein the chitosan fiber treated by application of glacial acetic acid exhibits enhanced hemostatic effect and bioadhesion to wet tissue when compared to untreated chitosan fiber. |
| Claim: | 14. The hemostatic material of claim 1 , wherein the chitosan fiber layers are secured to each other to form a net structure by treatment with an aqueous acetic acid solution of pH 3.0 to 4.5. |
| Claim: | 15. The hemostatic suture of claim 5 , wherein the chitosan fibers are secured to each other by treatment with an aqueous acetic acid solution of pH 3.0 to 4.5. |
| Claim: | 16. The hemostatic material of claim 1 , wherein surfaces of the chitosan fiber layers are further treated by misting with glacial acetic acid to form ammonium salt of chitosan. |
| Claim: | 17. The hemostatic suture of claim 5 , wherein the chitosan fibers are further treated by misting with glacial acetic acid to form ammonium salt of chitosan. |
| Current U.S. Class: | 424/443 |
| Patent References Cited: | 3533940 October 1970 Peniston et al. 4394373 July 1983 Malette 4452785 June 1984 Malette 4532134 July 1985 Malette 5836970 November 1998 Pandit 5885609 March 1999 Amiji 6060461 May 2000 Drake 6465626 October 2002 Watts et al. 6806260 October 2004 Hirofumi et al. 7098194 August 2006 Chenite et al. 2003/0206958 November 2003 Cattaneo et al. 2004/0054346 March 2004 Zhu et al. 20010079260 September 2001 WO 01/24840 April 2001 |
| Other References: | PCT International Search Report for PCT International Application No. PCT/US04/19043, mailed Jan. 5, 2006. cited by applicant Written Opinion of the International Searching Authority for PCT International Application No. PCT/US04/19043, mailed Jan. 5, 2006. cited by applicant Office action mailed Mar. 26, 2007 in co-pending U.S. Appl. No. 10/868,202. cited by applicant Wang et al., “Studies on hepatic arterial embolization with cisplatin-chitosan-microspheres in dogs” Abstract XP002476227, Medline Database Accession No. NLM8712014, Acta Pharmaceutica Sinica, Dec. 1995, vol. 30, No. 12, pp. 891-895. cited by applicant Heller et al., “Alginate/chitosan microporous microspheres for the controlled release of proteins and antigens”, Proceedings of the Controlled Release Society, 19096, No. 23, pp. 269-270. cited by applicant Tan et al., “Effectiveness of microporous polysaccharide hemospheres for achieving hemostasis in mohs micrograph surgery”, Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery, Jun. 2004, vol. 30, No. 6, pp. 908-914. cited by applicant Ereth et al., “Efficacy of Microporous Polysaccharide Hemospheres on Liver Punch biopsies in Porcine Model”, Anesthesiology Abstracts of Scientific Papers Annual Meeting, No. 2003, 2003, Abstract No. A-153 URL, Abstract XP002476226 & 2003 Annual Meeting of the American Society of Anesthesiologists, San Francisco, CA, Oct. 11-15, 2003. cited by applicant Supplemental European Search Report in European Appl. No. 04776473.3 dated May 2, 2008. cited by applicant PCT Notification of Transmittal of the International Search Report and the Written Opinion of the International Searching Authority mailed Sep. 19, 2006 in International Application No. PCT/US05/05239. cited by applicant Medafor, Ereth et al. “Microporous Polysaccharide Hemospheres Provide Effective Topical Hemostasis in a Human Modified Bleeding Time Inclusion Model”, Hemoostatic Polymer Technologies, Sep. 2002. cited by applicant Drake, J. F. “Fate of Porous Starch Microbeads in Mammalian Tissues”, Nov. 18, 2002. cited by applicant Everaers, et al. “Rheology and Microscopic Topology of Entangled Polymeric Liquids”, Science, vol. 202, Feb. 6, 2004. cited by applicant Pathology Report, “The Wound Healing Effects in Porcine Skin Grafts After Application of Microporous Polysaccharide Hemospheres (MPH)”, Aug. 14, 2002, Medafor, Inc., Minneapolis, MN. cited by applicant Viyoch, et al. “Formulation and Development of a Patch Containing Tamarind Fruit Extrat by Using the Blended Chitosan Starch as a Rate Controlling Matrix”, Intl. J of Cosmetic Science, V25 p. 113, 2003. cited by applicant Ziauddin, et al. “Use of Microporous Polysaccharide Particles in Prolonged Vascular Access Bleeding After Hemodialysis”, American Society of Nephrology, Friday, Nov. 1, 2002, Poster Board No. F-P0835. cited by applicant PCT International Search Report for PCT International Application No. PCT/US04/18575, mailed Apr. 7, 2005. cited by applicant Written Opinion of the International Searching Authority for PCT International Application No. PCT/US04/18575, mailed Apr. 7, 2005. cited by applicant |
| Primary Examiner: | Packard, Benjamin |
| Attorney, Agent or Firm: | Knobbe, Martens, Olson & Bear, LLP. |
| رقم الانضمام: | edspgr.08703176 |
| قاعدة البيانات: | USPTO Patent Grants |
| الوصف غير متاح. |