Patent
Antrocin containing pharmaceutical compositions for inhibiting cancer cells
| العنوان: | Antrocin containing pharmaceutical compositions for inhibiting cancer cells |
|---|---|
| Patent Number: | 8,580,847 |
| تاريخ النشر: | November 12, 2013 |
| Appl. No: | 13/337681 |
| Application Filed: | December 27, 2011 |
| مستخلص: | This subject invention is directed to a method for inhibition of cancer cells, comprising administrating an effective amount of a compound of formula I (Sesquiterpene lactones, antrocin) or pharmaceutically acceptable salts thereof, together with a pharmaceutically acceptable carrier, wherein the cancer cells are selected from colorectal cancer cells, liver cancer cells, lung cancer cells or breast cancer cells. |
| Inventors: | Tzeng, Yew-Min (Taichung, TW); Yang, Tien-Shen (Taichung, TW); Yeh, Chi-Tai Yeh (Taipei, TW) |
| Assignees: | Chaoyang University of Technology (Taichung County, TW) |
| Claim: | 1. A method for growth inhibition of cancer cells, comprising administering an effective amount of a compound of formula I—antrocin [chemical expression included] or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier, wherein the cancer cells are selected from colorectal cancer cells, liver cancer cells, lung cancer cells or breast cancer cells. |
| Claim: | 2. The method of claim 1 , wherein the formula I—antrocin is extracted from fruiting bodies of Antrodia camphorata with solvent under reflux and purified by silica gel column chromatography. |
| Claim: | 3. The method of claim 1 , wherein the effective amount of the compound of formula I—antrocin is a concentration of 0.5 to 50 μM for cancer cells inhibition. |
| Current U.S. Class: | 514/468 |
| Patent References Cited: | 2006/0251673 November 2006 Hwang et al. |
| Other References: | Chiang et al. Phytochemistry, 1995, vol. 39, No. 3, pp. 613-616. cited by examiner Yan et al. J. Chromatogr. A, 2004. vol. 1043, pp. 329-332. cited by examiner Rao et al. Chemical Research in Toxicology, Published online 2010, vol. 24, No. 2, pp. 238-245. cited by examiner |
| Primary Examiner: | Jean-Louis, Samira |
| Attorney, Agent or Firm: | WPAT, P.C. King, Anthony |
| رقم الانضمام: | edspgr.08580847 |
| قاعدة البيانات: | USPTO Patent Grants |
| الوصف غير متاح. |