Patent
Methods for treating sleep disorders by cholecystokinin (CCK) receptor B antagonists
| العنوان: | Methods for treating sleep disorders by cholecystokinin (CCK) receptor B antagonists |
|---|---|
| Patent Number: | 8,053,413 |
| تاريخ النشر: | November 08, 2011 |
| Appl. No: | 11/916563 |
| Application Filed: | June 06, 2006 |
| مستخلص: | The present invention relates to a method for preventing or ameliorating a sleep-related breathing disorder. The method involves the use of one or a combination of cholecystokinin (CCK) receptor antagonists. |
| Inventors: | Carley, David W. (Evanston, IL, US); Radulovacki, Miodrag (Chicago, IL, US) |
| Assignees: | The Board of Trustees of the University of Illinois (Chicago, IL, US) |
| Claim: | 1. A method for ameliorating sleep apnea comprising administering an effective amount of cholecystokinin (CCK) receptor B antagonist: [chemical expression included] CR2945, or L-365,260, to a subject in need of treatment thereby ameliorating the subject's sleep apnea. |
| Current U.S. Class: | 514/177 |
| Patent References Cited: | 4820834 April 1989 Evans et al. 5618811 April 1997 Lowe, III 5688943 November 1997 Ryder et al. 5728829 March 1998 Semple et al. 5962451 October 1999 Ryder et al. 6075033 June 2000 Makovec et al. 2004/0198723 October 2004 Gibson |
| Other References: | Burgess et al. J of Cell Bio. 1990, 111:2129-2138. cited by examiner Bowie et al. Science, 1990, 247:1306-1310. cited by examiner Pawson et al. 2003, Science 300:445-452. cited by examiner Widdop et al., “Electrophysiological and autoradiographical evidence for cholecystokinin A receptors on rat isolated nodose gangila”, J. Autonomic Nervous System 1993 46:65-73. cited by other Yoshioka et al., “Pharmacological Characterization of 5-Hydroxytryptamine-Induced Apnea in the Rat”, J. Pharmacology and Experimental Therapeutics 1992 260(2):917-924. cited by other DeMesquita et al., “Effect of chronic intracerebroventricular infusion of cholecystokinin on respiration and sleep”, Brain Research 1986 378:127-132. cited by other Bennet et al., “Apneic effects of cholecystokinin in unanaesthetized fetal sheep”, Journal of Developmental Physiology 1990 14:229-233. cited by other Herranz, Rosario, “Cholecystokinin Antagonists; Pharmacological and Therapeutic Potential”, Medicinal Research Reviews 2003 23(5) :559-605. cited by other Fourmy et al. “Structure of Cholecystokinin Receptor Binding Sites and Mechanism of Activation/Inactivation by Agonists/Antagonists” Pharmacology & Toxicology 2002 vol. 91: 313-320. cited by other Bock et al. “Cholecystokinin (CCK) Receptor Antagonists” Current Pharmaceutical Design Ed. Graham Johnson 1995 vol. 1(3) : 284-289. cited by other Gales et al. “Identification of Tyrosine 189 and Asparagine 358 of the Cholecystokinin 2 Receptor in Direct Interaction with the Crucial C-Terminal Amide of Cholecystokinin by Molecular Modeling, Site Directed Mutagenesis, and Structure/Affinity Studies” Molecular Pharmacology 2003 vol. 63(5) : 973-982. cited by other |
| Primary Examiner: | Wang, Chang-Yu |
| Attorney, Agent or Firm: | Licata & Tyrrell, P.C. |
| رقم الانضمام: | edspgr.08053413 |
| قاعدة البيانات: | USPTO Patent Grants |
| الوصف غير متاح. |