Patent
PEGylated soluble GP130-dimers useful as a medicament
| العنوان: | PEGylated soluble GP130-dimers useful as a medicament |
|---|---|
| Patent Number: | 7,629,147 |
| تاريخ النشر: | December 08, 2009 |
| Appl. No: | 12/026476 |
| Application Filed: | February 05, 2008 |
| مستخلص: | A polypeptide-dimer comprising two soluble gp130 molecules is described, wherein at least one of said soluble gp130 molecules is covalently linked to polyethylene glycol. Furthermore, a pharmaceutical composition containing said dimer and various medical uses are described. |
| Inventors: | Seegert, Dirk (Kiel, DE); Schreiber, Stefan (Kiel, DE); Rose-John, Stefan (Kiel, DE); Watzig, Georg H. (Kiel, DE); Rahaus, Nikolaus (Kiel, DE) |
| Assignees: | Conaris Research Institute AG (Kiel, DE) |
| Claim: | 1. A polynucleotide encoding a polypeptide-dimer comprising two soluble gp130 molecules or a monomer of said dimer, wherein at least one of said soluble gp130 molecules is covalently linked to polyethylene glycol wherein each of said soluble gp130 molecules consists of extracellular domains D1-D3 of gp130 that maintain the ability to inhibit the activity of agonistic complex IL-6/sIL-6R, and wherein at least one of said two soluble gp130 molecules comprises the amino acid sequence of SEQ ID NO: 2. |
| Claim: | 2. An isolated expression vector comprising the polynucleotide of claim 1 . |
| Claim: | 3. An isolated host cell comprising the expression vector of claim 2 . |
| Claim: | 4. A method of producing the polypeptide-dimer of claim 3 , comprising: culturing said host cell; recovering the polypeptide-monomer or dimer from said host cell or the culture; and PEGylating the monomers or dimers. |
| Current U.S. Class: | 435/691 |
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| Primary Examiner: | Mertz, Prema |
| Attorney, Agent or Firm: | Wilson Sonsini Goodrich & Rosati |
| رقم الانضمام: | edspgr.07629147 |
| قاعدة البيانات: | USPTO Patent Grants |
| الوصف غير متاح. |