Patent
Cyclic peptides and aids vaccines
| العنوان: | Cyclic peptides and aids vaccines |
|---|---|
| Patent Number: | 7,378,490 |
| تاريخ النشر: | May 27, 2008 |
| Appl. No: | 09/889845 |
| Application Filed: | November 05, 1999 |
| مستخلص: | Cyclic peptides comprising, as a constituent chain or chains, one or two amino acid sequences selected from the groups consisting of the amino acid sequence Glu-Ala-Asp-Asp-Arg and the amino acid sequence Ser-Gln-Lys-Glu-Gly, and AIDS vaccines containing the cyclic peptide as an active ingredient. Preferably a cyclic dodecapeptide represented by the formula given below and an AIDS vaccine containing the cyclic dodecapeptide as an active ingredient. From the in vivo absorption and antibody formation viewpoint, active groups selected from among the carboxyl, amino and hydroxyl groups contained in the cyclic peptide is preferably bound to substituent groups. The cyclic dodecapeptide can neutralize the second receptors in the infection of human with HIV-1 virus [chemical expression included] |
| Inventors: | Shoji, Shozo (Kumamoto, JP) |
| Assignees: | Nissui Pharmaceutical Co., Ltd. (JP) |
| Claim: | 1. A cyclic peptide represented by the formula: [chemical expression included] |
| Claim: | 2. A cyclic peptide as claimed in claim 1 , wherein a substituent group is bonded to at least one active group selected from among the carboxyl, amino and hydroxyl groups contained in the cyclic peptide. |
| Claim: | 3. A cyclic peptide as claimed in claim 2 wherein the substituent group is selected from among the residue of a fatty acid CH 3 (CH 2) n —COOH (n: 0 to 20), the residue of an alcohol CH 3 (CH 2) n —OH (n: 0 to 20) and the unsaturated compound residues corresponding to those compound residues. |
| Current U.S. Class: | 530/317 |
| Patent References Cited: | 0 551 689 January 1992 0 834 564 April 1998 08-027184 January 1996 WO 97/47319 December 1997 |
| Other References: | Feinberg, M. B., and J. P. Moore, 2002, “AIDS vaccine models: challenging challenge viruses.”, Nature Med. 8(3):207-210. cited by examiner Bende, S., and M. I. Johnston, 2000, “Update: search for an AIDS vaccine.”, AIDS Reader 526-538. cited by examiner Johnston, M. I., 2000, “The role of nonhuman primate models in AIDS vaccine development.”, Mol. Med. Today 6:267-270. cited by examiner Moore, J. P., and D. R. Burton, 1999, “HIV-1 neutralizing antibodies: how full is the bottle?”, Nature Med. 5(2):142-144. cited by examiner Burton, D. R., and J. P. Moore, 1998, “Why do we not have an HIV vaccine and how can wemake one?”, Nature Med. Vaccine Suppl. 4(5):495-498. cited by examiner Letvin, N. L., 1998, “Progress in the development of an HIV-1 vaccine.”, Science 280:1875-1880. cited by examiner Lee, T.-H., 1997, “Acquired immunodeficiency disease vaccines: design and development”, in AIDS: Biology, Diagnosis, Treatment and Prevention, fourth edition, DeVita, Jr., V. T., et al., eds., Lippincott-Raven Publishers, Philadelphia, PA, pp. 605-616. cited by examiner Haynes, B. F., et al., 1996, “Update on the issues of HIV vaccine development.”, Annals Med. 28:39-41. cited by examiner Feng, Y., Broder, C., Kennedy, P., Berger, E. Science., vol. 272. pp. 872-877. May 10, 1996. cited by other Liu, R. et al. Cell, vol. 86. pp. 367-377. Aug. 9, 1996. cited by other Olson, W. et al. Journal of Virology, vol. 73, No. 5. pp. 4145-4155. May 1999. cited by other Brelot, A., Heveker, N., Pleskoff, O., Sol., N., Alizon, M. Journal of Virology, vol. 71, No. 6. pp. 4744-4751. Jun. 1997. cited by other Biochemical and Biophysical Research Communications 285, 1309-1316 (2001). cited by other The Journal of Biological Chemistry, vol. 278, No. 34, Issue of Aug. 22, pp. 32335-32343, 2003. cited by other Stat Med. Jul. 30, 2003; 22(14):2281-98, On the analysis of viral load endpoints in HIV vaccine trials. cited by other Japan Pharmacology Academy Kyushu Branch Mass Meeting Lecture Summary Collection, pp. 43. cited by other |
| Primary Examiner: | Parkin, Jeffrey S. |
| Attorney, Agent or Firm: | Bacon & Thomas, PLLC |
| رقم الانضمام: | edspgr.07378490 |
| قاعدة البيانات: | USPTO Patent Grants |
| الوصف غير متاح. |