Patent
Mechanical heart valve and production method thereof
| العنوان: | Mechanical heart valve and production method thereof |
|---|---|
| Patent Number: | 6,875,230 |
| تاريخ النشر: | April 05, 2005 |
| Appl. No: | 10/111244 |
| Application Filed: | October 19, 2000 |
| مستخلص: | An artificial heart valve comprising a tubular base body having sinuse(s) of Valsalva and valve cusp(s) provided inside the base body, characterized in that the base body and the valve cusps comprise a bioabsorbable polymer material. |
| Inventors: | Morita, Shinichiro (Ayabe, JP); Nakamura, Saburo (Ayabe, JP); Hirata, Shigeyuki (Moriyama, JP); Shin'oka, Toshiharu (Tokyo, JP); Imai, Yasuharu (Tokyo, JP) |
| Assignees: | Gunze Limited (Kyoto, JP), Tokyo Women's Medical University (Tokyo, JP) |
| Claim: | 1. An artificial heart valve, comprising: a tubular base body having at least one sinus of Valsalva; and at least one valve cusp provided inside the base body, wherein both the sinus and the cusp are bioabsorbable, and at least one of the sinus or the cusp comprises a fibrous reinforcement structure made of a bioabsorbable polymer embedded in a porous bioabsorbable polymer material. |
| Claim: | 2. An artificial heart valve formed by seeding living cells into the artificial heart valve according to claim 1 . |
| Claim: | 3. The artificial heart valve according to claim 1 , wherein the bioabsorbable material is selected from the group consisting of polyglycolic acid, polylactic acid, polycaprolactone, glycolic acid-lactic acid copolymer, glycolic acid-caprolactone copolymer, lactic acid-caprolactone copolymer, poly(p-dioxanone), collagen, denatured collagen, gelatin, chitin, and chitosan. |
| Claim: | 4. A process for producing an artificial heart valve, comprising: forming at least one sinus of Valsalva which is bioabsorbable on a base body; and attaching at least one valve cusp which is bioabsorbable to the base body, wherein at least one of the sinus or the cusp is made by a method comprising: setting a fibrous reinforcement structure made of a bioabsorbable polymer in a mold; pouring a bioabsorbable polymer material into the mold; freezing the bioabsorbable polymer material; and lyophilizing the bioabsorbable polymer material. |
| Claim: | 5. The process according to claim 4 , wherein the attaching of the valve cusp comprises conducting by adhesion. |
| Claim: | 6. The process according to claim 4 , wherein the attaching of the valve cusp comprises conducting by suture. |
| Claim: | 7. The process according to claim 6 , wherein the suture is conducted using a bioabsorbable suture. |
| Claim: | 8. The process according to claim 4 , wherein the attaching of the valve cusp comprises conducting by thermal fusion. |
| Claim: | 9. The process according to claim 4 , wherein the attaching of the valve cusp comprises using a bioabsorbable polymer solution. |
| Claim: | 10. The process according to claim 4 , wherein the base body having the sinus of Valsalva is formed to be tubular by molding and one end of a substrate is folded and subjected to heat set so as to form the valve cusp. |
| Claim: | 11. The process according to claim 4 , wherein the bioabsorbable material is selected from the group consisting of polyglycolic acid, polylactic acid, polycaprolactone, glycolic acid-lactic acid copolymer, glycolic acid-caprolactone copolymer, lactic acid-caprolactone copolymer, poly(p-dioxanone), collagen, denatured collagen, gelatin, chitin, and chitosan. |
| Current U.S. Class: | 623/212 |
| Patent References Cited: | 4192020 March 1980 Davis et al. 4364127 December 1982 Pierce et al. 4510628 April 1985 Kolff 4728328 March 1988 Hughes et al. 4916193 April 1990 Tang et al. 5011494 April 1991 von Recum et al. 5139515 August 1992 Robicsek 5290494 March 1994 Coombes et al. 5489297 February 1996 Duran 5527337 June 1996 Stack et al. 5545215 August 1996 Duran 5700286 December 1997 Tartaglia et al. 5855610 January 1999 Vacanti et al. 6364905 April 2002 Simpson et al. 0 744 162 December 1997 11-503051 March 1999 WO 9002796 March 1990 WO 9608213 March 1996 WO 9631157 October 1996 WO 9911297 March 1999 WO 9947188 September 1999 |
| Assistant Examiner: | Sweet, Thomas J |
| Primary Examiner: | McDermott, Corrine |
| Attorney, Agent or Firm: | Knobbe, Martens Olsen & Bear LLP |
| رقم الانضمام: | edspgr.06875230 |
| قاعدة البيانات: | USPTO Patent Grants |
| الوصف غير متاح. |