Patent
Radioiodinated phospholipid ether analogues
| العنوان: | Radioiodinated phospholipid ether analogues |
|---|---|
| Patent Number: | 5,795,561 |
| تاريخ النشر: | August 18, 1998 |
| Appl. No: | 08/304,259 |
| Application Filed: | September 12, 1994 |
| مستخلص: | Novel radioiodinated analogues of naturally-occurring phospholipid ethers are tumor-specific and have a triglycerol backbone structure which, in certain embodiments, is substituted at the 3-position with an alkyl phosphocholine and include a monoiodinated benzoyl side chain substituted at the 2-position in accordance with the general formula: ##STR1## where n=1-15 ##STR2## M=0-15; Z=.sup.123 I, .sup.125 I, and .sup.131 I; Y=NH.sub.2, NR.sub.2, and NR.sub.3, and R=alkyl, aralkyl. |
| Inventors: | Counsell, Raymond E. (Ann Arbor, MI); Meyer, Karen L. (Norman, OK); Schwendner, Susan W. (Ann Arbor, MI); Haradahira, Terushi (Fukuoka, JPX) |
| Assignees: | The Board of Regents of the University of Michigan (Ann Arbor, MI) |
| Claim: | Wath is claimed is |
| Claim: | 1. A compound having the general formula: ##STR17## where n=1-15, except n=1-14 where m=0 and Y=--N((CH.sub.3).sub.3 ; X is selected from the group consisting of ##STR18## where m=0-15 and Z is a radioactive isotope of iodine; Y is selected from the group consisting of NH.sub.2, NR.sub.2, NR.sub.3 ; and R is selected from the group consisting of alkyl and aralkyl substituents. |
| Claim: | 2. The compound of claim 1 wherein Z is selected from the group consisting of .sup.122 I, .sup.123 I, .sup.125 I, and .sup.131 I. |
| Current U.S. Class: | 424/177; 424/165; 424/185 |
| Current International Class: | A61K 5100; A61M 3614 |
| Patent References Cited: | 3716631 February 1973 Steggerda et al. 4473544 September 1984 Maehulla et al. 4571332 February 1986 Schroit et al. 4925649 May 1990 Counsell et al. 4965391 October 1990 Counsell et al. 5061626 October 1991 Baldo et al. 5087721 February 1992 Counsell et al. 5347030 September 1994 Counsell et al. |
| Other References: | Andreesen et al., Cancer Research, vol. 38, pp. 3894-3899, Nov., 1978. March et al., Advanced Organic Chemistry, p. 1100, 1985. |
| Primary Examiner: | Kight, John |
| Assistant Examiner: | Jones, Dameron |
| Attorney, Agent or Firm: | Rohm & Monsanto |
| رقم الانضمام: | edspgr.05795561 |
| قاعدة البيانات: | USPTO Patent Grants |
| الوصف غير متاح. |