Patent
Des-21-threonine-calcitonin
| العنوان: | Des-21-threonine-calcitonin |
|---|---|
| Patent Number: | 4,604,237 |
| تاريخ النشر: | August 05, 1986 |
| Appl. No: | 06/673,300 |
| Application Filed: | November 20, 1984 |
| مستخلص: | New peptides are disclosed which have biological activity of the same type as known calcitonins and which do not have a threonine in position 21. The position 21 threonine is omitted. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides. |
| Inventors: | Orlowski, Ronald C. (Frankfort, IL); Seyler, Jay K. (Bourbonnais, IL); Stahl, Glenn L. (Bradley, IL) |
| Assignees: | Armour Pharmaceutical Company (Tarrytown, NY) |
| Claim: | What is claimed |
| Claim: | 1. A peptide having the structure: ##STR28## |
| Claim: | 2. A peptide having the structure: ##STR29## where R.sub.1 is S-n-alkyl, Cys or H and R.sub.2 is S-n-alkyl or H, R.sub.1 being S-n-alkyl, Cys or H when R.sub.2 is H and R.sub.2 being S-n-alkyl or H when R.sub.1 is H. |
| Claim: | 3. The compound of claim 1 which is des-21-threonine salmmon calcitonin. |
| Claim: | 4. The compound of claim 1 which is des-21-threonine eel calcitonin. |
| Claim: | 5. The compound of claim 1 which is des-21-threonine human calcitonin. |
| Claim: | 6. The compound 1,7-.alpha.-L-aminosuberic acid-des-20-threonine-salmon calcitonin having the structure: ##STR30## |
| Claim: | 7. The compound 1,7-.alpha.-L-aminosuberic acid-des-20-threonine-eel calcitonin having the structure: ##STR31## |
| Current U.S. Class: | 530/307 |
| Current International Class: | C07K 736 |
| Patent References Cited: | 4086221 April 1978 Sakakibara et al. 4451395 May 1984 Orlowski et al. |
| Other References: | Morikawa et al., Experientia, 32(9), 1104-1106 (1976). Gaddum, J. Pharm. Pharmacol., 6, 345-358 (1953). |
| Primary Examiner: | Phillips, Delbert R. |
| Assistant Examiner: | Moezie, F. T. |
| رقم الانضمام: | edspgr.04604237 |
| قاعدة البيانات: | USPTO Patent Grants |
| الوصف غير متاح. |