Patent
Des.sup.2 -glycine.sup.8 -des.sup.22 -calcitonin
| العنوان: | Des.sup.2 -glycine.sup.8 -des.sup.22 -calcitonin |
|---|---|
| Patent Number: | 4,597,900 |
| تاريخ النشر: | July 01, 1986 |
| Appl. No: | 06/525,356 |
| Application Filed: | August 22, 1983 |
| مستخلص: | New peptides are disclosed which have biological activity of the same type as known calcitonins and which have a shorter amino acid chain than natural calcitonins and are also substitution analogs of the natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides. |
| Inventors: | Orlowski, Ronald C. (Frankfort, IL); Seyler, Jay K. (Bourbonnais, IL) |
| Assignees: | Armour Pharmaceutical Co. (Tarrytown, NY) |
| Claim: | What is claimed |
| Claim: | 1. A peptide having the structure: ##STR27## |
| Claim: | 2. A peptide having the structure: ##STR28## where R.sub.1 is S-n-alkyl, Cys or H and R.sub.2 is S-n-alkyl or H, R.sub.1 being S-n-alkyl, Cys or H when R.sub.2 is H and R.sub.2 being S-n-alkyl or H when R.sub.1 is H, wherein the alkyl group is methyl, ethyl, propyl, or butyl. |
| Claim: | 3. Des-Ser.sup.2 -Gly.sup.8 -Des-Tyr.sup.22 -Calcitonin wherein the calcitonin is a salmon calcitonin analog. |
| Claim: | 4. Des-Ser.sup.2 -Gly.sup.8 -Des-Tyr.sup.22 -Calcitonin wherein the calcitonin is an eel calcitonin analog. |
| Current U.S. Class: | 530/307 |
| Current International Class: | C07K 736 |
| Patent References Cited: | 4217268 August 1980 Hughes et al. 4239680 December 1980 Hughes et al. 4401593 August 1983 Orlowski et al. 4451395 May 1984 Orlowski et al. |
| Other References: | Noda et al., J. Biochem., 79, 353-359 (1976). |
| Primary Examiner: | Phillips, Delbert R. |
| Assistant Examiner: | Moezie, F. T. |
| رقم الانضمام: | edspgr.04597900 |
| قاعدة البيانات: | USPTO Patent Grants |
| الوصف غير متاح. |