Patent
5,5-Difluorouracil
| العنوان: | 5,5-Difluorouracil |
|---|---|
| Patent Number: | 4,246,411 |
| تاريخ النشر: | January 20, 1981 |
| Appl. No: | 05/777,560 |
| Application Filed: | March 14, 1977 |
| مستخلص: | Direct fluorination of uracil, cytosine and their derivatives, in the presence of a non-aqueous solvent, by fluorine gas to produce 5-fluorouracil, 5-fluorocytosine, 5-fluorouracil derivatives and 5-fluorocytosine derivatives is disclosed. The non-aqueous solvent is an acid or alcohol, which can be partly or fully fluorinated or chlorinated, of up to 8 carbon atoms, such as trifluoroacetic acid. Novel compounds produced by the reaction, such as 5,5-difluoro-5,6-dihydro-6-(2,2,2-trifluoroethoxy) uracil are also disclosed. The derivatives and 5-fluorocytosine are useful as germicidal and antineoplastic agents while 5-fluorouracil itself is a known cancer chemotherapy agent. |
| Inventors: | Schuman, Paul D. (Hawthorne, FL); Westmoreland, Geraldine (Gainesville, FL); Anderson, Roy (Gainesville, FL) |
| Assignees: | PCR Incorporated (Gainesville, FL) |
| Claim: | What is claimed is |
| Claim: | 1. A compound of the formula ##STR22## |
| Current U.S. Class: | 544/313 |
| Current International Class: | C07D23954 |
| Patent References Cited: | 3846429 November 1974 Giller et al. 3954758 May 1976 Schuman et al. |
| Primary Examiner: | Coughlan, Jr., Paul M. |
| Attorney, Agent or Firm: | Murray and Whisenhunt |
| رقم الانضمام: | edspgr.04246411 |
| قاعدة البيانات: | USPTO Patent Grants |
| الوصف غير متاح. |