التفاصيل البيبلوغرافية
| العنوان: |
Molecular Heterobimetallic Chemodosimetric Sensor for the Detection of Biogenic Amines |
| Document Number: |
20110306140 |
| تاريخ النشر: |
December 15, 2011 |
| Appl. No: |
12/797763 |
| Application Filed: |
June 10, 2010 |
| مستخلص: |
The invention relates to using heterobimetallic coordination polymers and their uses as chemodosimeters for sensing materials for the screening of specific biogenic amines. |
| Inventors: |
LAM, Hon-Wah (Kowloon Tong, HK); CHOW, Cheuk-Fai (Ma Wan, HK) |
| Assignees: |
CITY UNIVERSITY OF HONG KONG (Kowloon, HK) |
| Claim: |
1. A method of detecting and/or measuring a biogenic amine or ammonia in a sample comprising: a. providing a complex of formula I MA-C≡N-MB (I), wherein MA is a Ru(II) complex and MB is a lanthanide metal complex; b. bringing the vapor of the sample into contact with said complex of formula I, whereby said biogenic amine or ammonia displaces the MA-C≡N portion of the complex of formula I from the MB portion; and c. detecting the presence of displaced MA-C≡N by measuring a colorimetric response. |
| Claim: |
2. A method according to claim 1 wherein the complex is of formula Ia MA-C≡N-MB-N≡C-MA (Ia). |
| Claim: |
3. A method for detecting and/or measuring a biogenic amine or ammonia in a food sample, comprising a. providing a complex of formula I MA-C≡N-MB(I), wherein MA is a Ru(II) complex and MB is a lanthanide metal complex; b. exposing the complex to a food product; and c. detecting any change in color, said detected change being indicative of the presence of biogenic amine or ammonia in, on or in association with, the food product. |
| Claim: |
4. A method according to claim 3 wherein the complex is of formula Ia MA-C≡N-MB-N≡C-MA (Ia). |
| Claim: |
5. A method according to claim 2 comprising bringing the vapor of said sample into contact with a complex of formula Ic [chemical expression included] wherein R1 in each instance is selected from (C1-C6)alkyl, phenyl, halogen and (C1-C6)alkoxy, and wherein R1 may be located at any of the 3, 3′, 4, 4′, 5 and 5′ positions on the bipyridine rings. |
| Claim: |
6. A method according to claim 5 comprising bringing the vapor of said sample into contact with a complex of formula II [chemical expression included] and detecting a colorimetric response. |
| Claim: |
7. A method according to claim 5 wherein the sample comprises ammonia or an amine with aliphatic or aromatic amino functionality. |
| Claim: |
8. A method according to claim 7 wherein the amine is selected from histamine, spermidine, putrescine, cadaverine and aniline. |
| Claim: |
9. A method according to claim 1 wherein the complex is in a suitable solvent. |
| Claim: |
10. A method according to claim 1 wherein the vapor of the sample is brought into contact with the complex. |
| Claim: |
11. A method according to claim 1 wherein the colorimetric response is ultraviolet or visible light or emission. |
| Claim: |
12. A process for preparing a complex of formula I [chemical expression included] comprising mixing a 2:1 ratio of K2[Ru(4,4′-Di-tert-butyl-2,2′-bipyridine)CN)4] and EuCl3.6H2O together in a 1:1 mixture of water and alkanol. |
| Claim: |
13. A sensor for detecting and/or measuring the presence of a biogenic amine or ammonia in, on or in association with a fluid which comprises a complex of the general formula MA-C≡N-MB (I) and a support structure having a surface, the complex being attached to the support structure as a coating thereon, wherein said complex undergoes a detectable color change upon exposure to a biogenic amine or ammonia. |
| Claim: |
14. The sensor of claim 13 wherein the structure comprises a plastic sheet, film or tray food packaging or a gas permeable film or membrane. |
| Claim: |
15. A sensor of claim 13 wherein said complex is of formula II [chemical expression included] |
| Claim: |
16. A sensor of claim 13 wherein the fluid contains ammonia or an amine with aliphatic or aromatic amino functionality. |
| Claim: |
17. A sensor of claim 16 wherein the amine is selected from histamine, spermidine, putrescine, cadaverine and aniline. |
| Claim: |
18. A sensor of claim 13 wherein the complex is in a suitable solvent. |
| Claim: |
19. A sensor of claim 13 wherein the vapor of the fluid is brought into contact with the complex. |
| Claim: |
20. A sensor of claim 13 wherein the colorimetric response is ultraviolet or visible light or emission. |
| Claim: |
21. A complex of formula Ic: [chemical expression included] wherein R1 in each instance is selected from (C1-C6)alkyl, phenyl, halogen and (C1-C6)alkoxy, and wherein R1 may be located at any of the 3, 3′, 4, 4′, 5 and 5′ positions on the bipyridine rings. |
| Claim: |
22. A complex according to claim 21 of formula II [chemical expression included] |
| Claim: |
23. A food container comprising the complex of formula I MA-C≡N-MB (I). |
| Claim: |
24. A food container comprising the complex of formula II [chemical expression included] |
| Claim: |
25-33. (canceled) |
| Current U.S. Class: |
436/20 |
| Current International Class: |
01; 01; 07; 65 |
| رقم الانضمام: |
edspap.20110306140 |
| قاعدة البيانات: |
USPTO Patent Applications |