التفاصيل البيبلوغرافية
| العنوان: |
MICROPARTICLE DISPERSION LIQUID MANUFACTURING METHOD AND MICROPARTICLE DISPERSION LIQUID MANUFACTURING APPARATUS |
| Document Number: |
20110285043 |
| تاريخ النشر: |
November 24, 2011 |
| Appl. No: |
13/195373 |
| Application Filed: |
August 01, 2011 |
| مستخلص: |
In a dissolving step, a poorly soluble drug and a dispersion stabilizer are dissolved in a volatile organic solvent. In a fixing step, the organic solvent, contained in a solution obtained in the dissolving step, is removed by evaporation, pellet-form residues 1 are obtained by the organic solvent removal, and the residues 1 are fixed on respective bottom surfaces of a plurality of locations of a container 30. In a water injecting step, water 2 is injected into each of a plurality of recesses 31 of the container 30. In an irradiating step, laser light L, emitted from a light irradiating unit 20, is irradiated simultaneously or successively on the residues 1 fixed on the respective bottom surfaces of the recesses 31 of the container 30, and the residues 1 are thereby pulverized and made into microparticles and a microparticle dispersion liquid, constituted of the microparticles being dispersed in the water 2, is manufactured. |
| Inventors: |
TAKEBE, Gen (Hamamatsu-shi, JP); Takagi, Tokio (Hamamatsu-shi, JP); Hiramatsu, Mitsuo (Hamamatsu-shi, JP) |
| Claim: |
1. A microparticle dispersion liquid manufacturing method comprising: a dissolving step of dissolving a poorly soluble drug and a dispersion stabilizer in a volatile organic solvent; a fixing step of performing removal by evaporation of the organic solvent, contained in a solution obtained in the dissolving step, and fixing a residue, obtained by the organic solvent removal, on each of a plurality of locations of an inner wall of a container; a water injecting step of injecting water into an interior of the container after the fixing step; and an irradiating step of irradiating light on the residues fixed on the respective locations of the inner wall of the container after the water injecting step to manufacture a liquid having microparticles, containing the poorly soluble drug and the dispersion stabilizer, dispersed in water. |
| Claim: |
2. The microparticle dispersion liquid manufacturing method according to claim 1, wherein a container with a plurality of recesses is used to fix the residues on respective bottom surfaces of the recesses in the fixing step, water is injected into each of the recesses of the container in the water injecting step, and, in the irradiating step, the light is irradiated on the residues fixed on the respective bottom surfaces of the recesses. |
| Claim: |
3. The microparticle dispersion liquid manufacturing method according to claim 2, wherein the respective bottom surfaces of the recesses of the container are composed of glass, and in the irradiating step, the light is irradiated from outside the respective bottom surfaces of the recesses of the container and the irradiated light is made to propagate in the order of the bottom surfaces, the residues, and the water. |
| Claim: |
4. The microparticle dispersion liquid manufacturing method according to claim 2, wherein the respective bottom surfaces of the recesses of the container are flat surfaces, and in the irradiating step, the light is irradiated from outside the respective bottom surfaces of the recesses of the container and the irradiated light is made to propagate in the order of the bottom surfaces, the residues, and the water. |
| Claim: |
5. The microparticle dispersion liquid manufacturing method according to claim 1, wherein in the irradiating step, light output from a light source is branched by a branching unit and irradiated simultaneously on the residues fixed on the respective locations of the inner wall of the container. |
| Claim: |
6. The microparticle dispersion liquid manufacturing method according to claim 1, wherein in the irradiating step, the light output from the light source is diffracted by a diffracting unit and irradiated simultaneously on the residues fixed on the respective locations of the inner wall of the container. |
| Claim: |
7. The microparticle dispersion liquid manufacturing method according to claim 1, wherein in the irradiating step, the light output from the light source is scanned by a scanning unit and irradiated successively on the residues fixed on the respective locations of the inner wall of the container. |
| Claim: |
8-14. (canceled) |
| Claim: |
15. A microparticle dispersion liquid manufacturing method comprising: a dissolving step of dissolving a poorly soluble drug and a dispersion stabilizer in a volatile organic solvent; a fixing step of performing removal by evaporation of the organic solvent, contained in a solution obtained in the dissolving step, and fixing a residue, obtained by the organic solvent removal, on an inner wall of a container; and an irradiating step of injecting water into an interior of the container after the fixing step and, while making the water flow near an interface of the residue and the water in the interior of the container, irradiating light on the residue fixed on the inner wall of the container to manufacture a microparticle dispersion liquid having microparticles, containing the poorly soluble drug and the dispersion stabilizer, dispersed in water. |
| Claim: |
16. The microparticle dispersion liquid manufacturing method according to claim 15, wherein in the irradiating step, the water injected into the interior of the container is stirred and the water is thereby made to flow near the interface of the residue and the water in the interior of the container. |
| Claim: |
17. The microparticle dispersion liquid manufacturing method according to claim 15, wherein in the irradiating step, the water injected into the interior of the container is vibrated and the water is thereby made to flow near the interface of the residue and the water in the interior of the container. |
| Claim: |
18. The microparticle dispersion liquid manufacturing method according to claim 15, wherein in the irradiating step, water is fed into the interior of the container and the water is thereby made to flow near the interface of the residue and the water in the interior of the container. |
| Claim: |
19. The microparticle dispersion liquid manufacturing method according to claim 18, wherein in the irradiating step, a temperature of the water fed into the interior of the container is maintained fixed. |
| Claim: |
20. The microparticle dispersion liquid manufacturing method according to claim 18, wherein in the irradiating step, the microparticle dispersion liquid manufactured in the interior of the container is collected in a collection container other than the container. |
| Claim: |
21. The microparticle dispersion liquid manufacturing method according to claim 20, wherein in the irradiating step, feeding of water and feeding of a gas into the interior of the container are performed alternately and the microparticle dispersion liquid is collected in the collection container during the feeding of the gas. |
| Claim: |
22-28. (canceled) |
| Current U.S. Class: |
264/7 |
| Current International Class: |
29 |
| رقم الانضمام: |
edspap.20110285043 |
| قاعدة البيانات: |
USPTO Patent Applications |