التفاصيل البيبلوغرافية
| العنوان: |
MEDICINAL COMPOSITION CONTAINING BENZO[A]PHENOXAZINE COMPOUND AS THE ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF PROTOZOAL DISEASE |
| Document Number: |
20110021450 |
| تاريخ النشر: |
January 27, 2011 |
| Appl. No: |
12/921569 |
| Application Filed: |
March 11, 2009 |
| مستخلص: |
Provided is a medicinal composition, in particular, a medicinal composition for treatment and/or prevention which has a high therapeutic effect on infection with a parasitic protozoa and a selective toxicity thereto and exhibits a life-prolonging effect and so on. A medicinal composition which contains as the active ingredient a benzo[a]phenoxazine compound represented by General formula (1) or a salt compound of the same, in particular, an agent for treating and/or preventing infection with a protozoa such as malaria, leishmaniasis, African trypanosomiasis, Chagas disease, toxoplasmosis, lymphatic filariasis, babesiosis or coccidium disease; and a novel compound which is contained therein as the active ingredient. |
| Inventors: |
Ihara, Masataka (Tokyo, JP); Ge, Jian-Feng (Tokyo, JP); Arai, Chika (Tokyo, JP); Yang, Mei (Tokyo, JP); Itoh, Isamu (Tokyo, JP); Brun, Reto (Basel, CH) |
| Assignees: |
HOSHI UNIVERSITY (Shinagawa-ku, Tokyo, JP), SYNSTAR JAPAN CO., LTD. (Yokohama-shi, Kanagawa, JP), SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE (Basel, CH) |
| Claim: |
1-12. (canceled) |
| Claim: |
13. A compound represented by any one of the following Structural Formulae 1B to 1H, 1J to 1M, 1P, 1R to 1T, and 1a to 1h, or a salt thereof: [chemical expression included] [chemical expression included] [chemical expression included] [chemical expression included] |
| Claim: |
14. The compound or salt according to claim 13, wherein the compound or salt is a compound represented by Structural Formula 1B or a salt thereof. |
| Claim: |
15. The medical composition for prevention or treatment of a protozoal disease, the medical composition comprising, as an active ingredient, the compound or salt according to claim 13. |
| Claim: |
16. The medical composition for prevention or treatment of a protozoal disease according to claim 15, further comprising chloroquine, mefloquine, artemisinin, atavaquone, pyrimethamine, suramin, pentamidine, melarsoprol, ascofuranone, benznidazole, pentostam, Amphotericin B, miltefosine, or fluconazole. |
| Claim: |
17. The medical composition for prevention or treatment of a protozoal disease according to claim 15, further comprising a medicinal carrier or a diluent. |
| Claim: |
18. The medical composition for prevention or treatment of a protozoal disease according to claim 15, wherein the content of the active ingredient in the medical composition is from 1 mg to 10,000 mg. |
| Claim: |
19. The medical composition for prevention or treatment of a protozoal disease according to claim 15, wherein the content of the active ingredient in the medical composition is from 10 mg to 3,000 mg. |
| Claim: |
20. The medical composition for prevention or treatment of a protozoal disease according to claim 15, wherein the medical composition is in the form of a liquid, tablet, or colloid. |
| Claim: |
21. A method of preventing or treating a protozoal disease, the method comprising administering, to a patient in need of prevention or treatment, a medical composition for prevention or treatment of a protozoal disease that includes, as an active ingredient, the compound or salt according to claim 13. |
| Claim: |
22. The method of preventing or treating a protozoal disease according to claim 21, wherein the active ingredient is represented by the following structural formula 1B: [chemical expression included] |
| Claim: |
23. The method of preventing or treating a protozoal disease according to claim 21, wherein the protozoal disease is malariosis, leishmaniasis, African sleeping sickness, Chagas disease, toxoplasmosis, lymphatic filariasis, babesiosis or coccidiosis. |
| Claim: |
24. The method of preventing or treating a protozoal disease according to claim 21, wherein the protozoal disease is malariosis, leishmaniasis, African sleeping sickness, or Chagas disease. |
| Claim: |
25. The method of preventing or treating a protozoal disease according to claim 21, wherein the medical composition further comprises chloroquine, mefloquine, artemisinin, atavaquone, pyrimethamine, suramin, pentamidine, melarsoprol, ascofuranone, benznidazole, pentostam, Amphotericin B, miltefosine, or fluconazole. |
| Claim: |
26. The method of preventing or treating a protozoal disease according to claim 21, wherein the medical composition further comprises a medicinal carrier or a diluent. |
| Claim: |
27. The method of preventing or treating a protozoal disease according to claim 21, wherein the content of the active ingredient in the medical composition is from 1 mg to 10,000 mg. |
| Claim: |
28. The method of preventing or treating a protozoal disease according to claim 21, wherein the content of the active ingredient in the medical composition is from 10 mg to 3,000 mg. |
| Claim: |
29. The method of preventing or treating a protozoal disease according to claim 21, wherein the medical composition is in the form of a liquid, tablet, or colloid. |
| Current U.S. Class: |
514/31 |
| Current International Class: |
61; 07; 61; 61; 61; 61 |
| رقم الانضمام: |
edspap.20110021450 |
| قاعدة البيانات: |
USPTO Patent Applications |