التفاصيل البيبلوغرافية
| العنوان: |
ADSORPTION AND RELEASE OF NITRIC OXIDE IN METAL ORGANIC FRAMEWORKS |
| Document Number: |
20100239512 |
| تاريخ النشر: |
September 23, 2010 |
| Appl. No: |
12/377429 |
| Application Filed: |
August 16, 2007 |
| مستخلص: |
Disclosed are metal organic frameworks that adsorb nitric oxide, NO-loaded metal organic frameworks, methods of preparing the NO-loaded metal organic frameworks, methods of releasing the nitric oxide into a solution or into air, and uses of the metal organic frameworks. |
| Inventors: |
Morris, Russell Edward (St. Andrews, GB); Wheatley, Paul Stewart (St. Andrews, GB) |
| Claim: |
1. A material comprising a metal organic framework which comprises adsorbed nitric oxide. |
| Claim: |
2. A material according to claim 1, which comprises a three dimensional network in which metal ions are linked together with ligand linkers (L). |
| Claim: |
3. A material according to claim 2, wherein the metal ions comprise any of a number of metal cations or mixtures thereof selected from transition metal cations, alkali metal cations, alkaline earth metal cations and other suitable metal cations, including aluminium cations. |
| Claim: |
4. A material according to claim 3, wherein the transition metal cations include one or more of: Tin+, Vn+, Crn+, Mnn+, Fen+, Con+, Nin+, Cun+, Znn+, Agn+, Run+, Rhn+ where n is 1, 2, 3 or 4. |
| Claim: |
5. A material according to claim 4, wherein the transition metal cations are selected from Cu+, Cu2+, Cr2+, Zn2+, Fe2+, Fe3+, Co2+, Co3+, Ag+, Mn2+ and Mn3+ and mixtures thereof. |
| Claim: |
6. A material according to any one of claims 3 to 5, wherein the alkali metal cations include Na+ and K+, and the alkaline earth metal cations include Ca2+ and Mg2+. |
| Claim: |
7. A material according to any preceding claim, wherein the ligand linkers (L) comprise organic compounds containing multiple coordinating atoms, sites or functional groups. |
| Claim: |
8. A material according to claim 7, wherein each ligand L includes 2-10 coordinating sites. |
| Claim: |
9. A material according to claim 7 or claim 8, wherein the coordinating sites may provide an electron donating moiety, a negative charge, or atoms or groups capable of forming such moieties. |
| Claim: |
10. A material according to any one of claims 7 to 9, wherein each ligand is a dentate ligand selected from bidentate and tridentate. |
| Claim: |
11. A material according to any one of claims 7 to 10, wherein the ligands are selected from carboxylate ligands or amine ligands. |
| Claim: |
12. A material according to claim 11, wherein the carboxylate ligands are selected from 1,4-benzene-dicarboxylic acid, 1,3,5-benzene tricarboxylic acid and 5-sulfoisophthalic acid. |
| Claim: |
13. A material according to claim 11 or claim 12, wherein the amine ligand is 1,4-bipyridine. |
| Claim: |
14. A material according to any preceding claim additionally comprising anions selected from halogens, OH− or SO4−. |
| Claim: |
15. A material according to any preceding claim, which is sealed inside airtight packaging. |
| Claim: |
16. A material according to any preceding claim, in the form of a powder or monolith. |
| Claim: |
17. A material according to claim 16, wherein the monolith is formed by compression of a metal organic framework powder or by mixing a powdered metal organic framework with a binder. |
| Claim: |
18. A material according to claim 17, wherein the binder is selected from ceramic binders, polymeric binders and other polymers. |
| Claim: |
19. A method of preparing a metal organic material which comprises releasably adsorbed nitric, said method comprising the steps of providing said metal organic material and contacting said metal organic material with nitric oxide. |
| Claim: |
20. A method according to claim 19, wherein, prior to contact with nitric oxide, the metal organic framework is fully or partially activated by removing guest molecules or species from interior pores and/or channels of the framework to allow the nitric oxide to be adsorbed into the metal organic framework. |
| Claim: |
21. A method according to claim 20, wherein activation of the metal organic framework is achieved chemically, optionally followed by other non-chemical means or vice versa. |
| Claim: |
22. A method according to claim 21, wherein the chemical activation removes guest molecules from the framework by chemical displacement of the guest molecules by the molecules of the activating chemical species. |
| Claim: |
23. A method according to claim 21, wherein the non-chemical means for activation includes heating the metal organic framework at atmospheric or reduced pressure, or subjecting the framework material to reduced pressure in absence of heat. |
| Claim: |
24. A method according to claim 22, wherein the activating chemical species include solvents selected from the group consisting of acetonitrile (CH3CN), dimethylformamide (DMF), ethanol (EtOH) or methanol (MeOH). |
| Claim: |
25. A method according to any one of claims 19 to 24, wherein the guest molecules comprise water so that activation of the framework includes full or partial dehydration of the framework material. |
| Claim: |
26. A method according to any one of claims 19 to 25, wherein the metal organic material is contacted with nitric oxide at a temperature of from −100° C. to 50° C. |
| Claim: |
27. A method according to any one of claims 19 to 26, wherein the nitric oxide is provided as substantially pure nitric oxide gas or as a mixture of nitric oxide gas and a carrier gas. |
| Claim: |
28. A method according to claim 27, wherein the carrier gas is an inert gas chosen from helium, argon or other inert gas including mixtures thereof. |
| Claim: |
29. A method according to any one of claims 19 to 28, wherein the metal organic material is contacted with nitric oxide gas at a pressure of from about atmospheric pressure up to a pressure of about 10 bar. |
| Claim: |
30. A metal organic framework material comprising releasably adsorbed nitric oxide for use in surgery and/or therapy. |
| Claim: |
31. A pharmaceutical, neutraceutical or cosmetic preparation comprising a metal organic framework material comprising releasably adsorbed nitric oxide together with a pharmaceutical/neutraceutical/cosmetic carrier therefor. |
| Claim: |
32. Use of a metal organic framework material comprising releasably adsorbed nitric oxide for the preparation of a medicament for use in the treatment or prophylaxis of disease. |
| Claim: |
33. Use according to claim 32, wherein the diseases or medical conditions are selected from the group consisting of infections of the skin, dermatophyte fungi, leishmaniasis, molluscum and papilloma virus, and mycobacterium infections; therapeutic applications in anti-neoplastic activities, immune response modification, treatment of Raynaud's disease, wound healing and skin pigment modification; treatment of restenosis, psoriasis eczema, and skin cancer (melanoma); therapies for bacterial problems, the reduction of severe foot or body odour, and in the treatment of Methicillin Resistant Staphylococcus Aureus infections. |
| Claim: |
34. A medical article comprising a metal organic framework material. |
| Claim: |
35. A medical article according to claim 34, wherein the article is coated with the metal organic framework material. |
| Claim: |
36. A medical article according to claim 34 or claim 35, wherein the metal organic framework material of the medical article is provided without nitric oxide loaded therein. |
| Claim: |
37. A medical article according to claim 34, wherein the metal organic framework material of the medical article is provided as a metal organic framework material comprising releasably adsorbed nitric oxide. |
| Claim: |
38. A medical article according to any one of claims 34 to 38, wherein the medical article is chosen from the group consisting of a stent, catheter, wound dressing, bandage, self-adhesive plaster and patch. |
| Claim: |
39. Use of a metal organic framework material comprising releasably adsorbed nitric oxide in cosmetic and/or personal hygiene application. |
| Claim: |
40. Use according to claim 39, in cosmetic preparations; deodorants; skin preparations, anti-aging skin preparations and preparations applied before, during or after hair removal by shaving or by application of depilatory preparations; hair preparations; depilatory preparations and the like. |
| Claim: |
41. A cosmetic and/or personal hygiene product comprising a metal organic framework material which comprises releasably adsorbed nitric oxide. |
| Claim: |
42. A method of preparing a medical article, cosmetic and/or personal hygiene product comprising the steps of: (i) providing a medical article, cosmetic and/or personal hygiene product which comprises a metal organic framework material without nitric oxide adsorbed therein, and (ii) contacting said medical article, cosmetic and/or personal hygiene product with nitric oxide. |
| Claim: |
43. A method of releasing nitric oxide comprising the steps of: (i) providing a metal organic framework material comprising releasably adsorbed nitric oxide; and (ii) contacting said metal organic framework material with a medium into which said nitric oxide is to be released. |
| Claim: |
44. A method according to claim 43, wherein the medium into which the nitric oxide is to be released is air or an aqueous medium. |
| Claim: |
45. A method according to claim 43 or claim 44, wherein the release is performed inside an animal body, topically to an animal body or ex vivo in non-body applications. |
| Claim: |
46. A method according to claim 54, wherein the release in non-body applications includes release into cell cultures. |
| Claim: |
47. A method according to any one of claims 43 to 46, wherein the release is performed at room temperature or body temperature. |
| Claim: |
48. A method of treatment of an individual in need thereof comprising providing a metal organic framework material comprising releasably adsorbed nitric oxide and contacting said metal organic framework material with said individual. |
| Claim: |
49. Use of a metal organic framework material for removing nitric oxide from a gas. |
| Claim: |
50. Use according to claim 49, wherein the metal organic framework material is in combination with a de Nox catalyst. |
| Claim: |
51. Use according to claim 49 or claim 50, wherein the gas is a gas stream. |
| Claim: |
52. Use according to any one of claims 49 to 51, wherein the gas is a combustion engine exhaust gas(es). |
| Claim: |
53. A catalyst comprising a metal organic framework material. |
| Claim: |
54. A metal organic framework material of formula (I): M3(BTC)2(R1R2R3N)3x(H2O)3-3x.n(Guest) (I) wherein, M is a divalent cation; BTC is benzene tricarboxylate; R1R2R3N is an amine where R1, R2 and R3 are independently hydrogen or an organic group; (Guest) is any number of independently selected species or molecules present in the pores of the material; x is a variable number from 0 to 1 including any incremental fraction between 0 and 1; and n is a variable from zero upwards. |
| Claim: |
55. A material according to claim 54, wherein M is Cu2+ or Cr2+. |
| Claim: |
56. A material according to claim 54 or claim 55, wherein the organic group is an alkyl group. |
| Claim: |
57. A material according to claim 56, wherein the alkyl group is a C1-C6alkyl group. |
| Claim: |
58. A material according to any one of claims 54 to 57, wherein each of R1, R2 and R3 is hydrogen or one of R1, R2 and R3 is methyl, and the remaining two R groups are hydrogen. |
| Claim: |
59. A material according to any one of claims 54 to 58, wherein the (Guest) species, is the amine R1R2R3N, water or a solvent or part of a solvent. |
| Claim: |
60. A material according to any one of claims 54 to 59, wherein n is from 0 to 30. |
| Claim: |
61. A material of formula: Cu3(BTC)2(NH3)3x(H2O)3-3x.n(Guest), wherein, (Guest) is any number of independently selected species or molecules present in the pores of the material; x is a variable number from 0 to 1 including any incremental fraction between 0 and 1; and n is a variable from zero upwards. |
| Claim: |
62. A method of preparing a metal organic framework material, the method comprising the steps of: (i) providing and combining within a vessel a metal salt, a ligand compound, choline chloride and a urea; and (ii) heating the combined components of step (i) to provide the metal organic framework. |
| Claim: |
63. A method according to claim 62, wherein the ligand component is benzene tricarboxylate (BTC). |
| Claim: |
64. A method according to claim 62 or claim 63, wherein the metal organic framework material has the formula (I): M3(BTC))2(R1R2R3N)3x(H2O)3-3x.n(Guest) (I) wherein, M is a divalent cation; BTC is benzene tricarboxylate; R1R2R3N is an amine where R1, R2 and R3 are independently hydrogen or an organic group; (Guest) is any number of independently selected species or molecules present in the pores of the material; x is a variable number from 0 to 1 including any incremental fraction between 0 and 1; and n is a variable from zero upwards. |
| Claim: |
65. A method according to any one of claims 62 to 64, wherein the combined components are heated by the action of microwaves at a temperature of from about 50° C. to about 150° C. |
| Claim: |
66. A method according to any one of claims 62 to 65, wherein the urea has the formula R4R5NCONR6R7, wherein R4, R5, R6 and R7 independently are hydrogen or an organic group. |
| Claim: |
67. A method according to claim 66, wherein each of R4, R5, R6 and R7 are hydrogen. |
| Claim: |
68. A method according to claim 66, wherein the urea has the formula H3CHNCONHCH3. |
| Current U.S. Class: |
424/65 |
| Current International Class: |
61; 07; 07; 61; 61; 61; 61; 61; 61; 61; 61; 61; 61; 61; 61 |
| رقم الانضمام: |
edspap.20100239512 |
| قاعدة البيانات: |
USPTO Patent Applications |