التفاصيل البيبلوغرافية
| العنوان: |
B7-related nucleic acids and polypeptides useful for immunomodulation |
| Document Number: |
20100125127 |
| تاريخ النشر: |
May 20, 2010 |
| Appl. No: |
12/069064 |
| Application Filed: |
February 07, 2008 |
| مستخلص: |
The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject. |
| Inventors: |
Mikesell, Glen E. (Pacifica, CA, US); Shen, Henry (Princeton, NJ, US); Chang, Han (Princeton Junction, NJ, US); Finger, Joshua N. (Spring City, PA, US); Yang, Guchen (Princeton, NJ, US); Peach, Robert James (San Diego, CA, US) |
| Claim: |
1-13. (canceled) |
| Claim: |
14. An isolated polypeptide comprising a sequence selected from the group consisting of: (a) an isolated polypeptide comprising amino acids 1 to 316 of SEQ ID NO: 13; (b) an isolated polypeptide comprising amino acids 2 to 316 of SEQ ID NO: 13; and (c) an isolated polypeptide comprising amino acids 29 to 316 of SEQ ID NO: 13. |
| Claim: |
15. The isolated polypeptide of claim 14, wherein said polypeptide is (a). |
| Claim: |
16. The isolated polypeptide of claim 14, wherein said polypeptide is (b). |
| Claim: |
17. The isolated polypeptide of claim 14, wherein said polypeptide is (c). |
| Claim: |
18. An isolated polypeptide comprising a polypeptide encoded by the cDNA clone contained in plasmid BSL2-L165-35b in ATCC Deposit No. PTA-1988. |
| Claim: |
19. An isolated polypeptide produced by a method comprising: (a) culturing an isolated recombinant host cell comprising a vector that comprises the coding region encoding the polypeptide of claim 14 under conditions such that said polypeptide is expressed; and (b) recovering said polypeptide. |
| Claim: |
20. The isolated polypeptide of claim 14 wherein said polypeptide further comprises a heterologous polypeptide. |
| Claim: |
21. The isolated polypeptide of claim 20 wherein said heterologous polypeptide is the Fc domain of human IgG. |
| Claim: |
22. An isolated polypeptide comprising a polypeptide encoded by the cDNA clone contained in plasmid BSL2v1c2Ig in ATCC Deposit No. PTA-4056. |
| Claim: |
23. An isolated polypeptide comprising a sequence selected from the group consisting of: (a) an isolated polypeptide comprising amino acids 1 to 247 of SEQ ID NO: 13; (b) an isolated polypeptide comprising amino acids 2 to 247 of SEQ ID NO: 13; and (c) an isolated polypeptide comprising amino acids 29 to 247 of SEQ ID NO: 13. |
| Claim: |
24. The isolated polypeptide of claim 23, wherein said polypeptide is (a). |
| Claim: |
25. The isolated polypeptide of claim 23, wherein said polypeptide is (b). |
| Claim: |
26. The isolated polypeptide of claim 23, wherein said polypeptide is (c). |
| Claim: |
27. The isolated polypeptide of claim 14, wherein said polypeptide contains a single amino acid substitution. |
| Current U.S. Class: |
530/324 |
| Current International Class: |
07; 07; 07; 07; 07; 07; 07; 07 |
| رقم الانضمام: |
edspap.20100125127 |
| قاعدة البيانات: |
USPTO Patent Applications |