التفاصيل البيبلوغرافية
| العنوان: |
NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS AND USES THEREOF |
| Document Number: |
20100093814 |
| تاريخ النشر: |
April 15, 2010 |
| Appl. No: |
12/274105 |
| Application Filed: |
November 19, 2008 |
| مستخلص: |
The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, [chemical expression included] wherein R1, R2, R3, R4, and L1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, [chemical expression included] wherein R1a, R2a, Rx, and n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. |
| Inventors: |
Florjancic, Alan S. (Kenosha, WI, US); Dart, Michael J. (Highland Park, IL, US); Ryther, Keith B. (Evansville, IN, US); Perez-Medrano, Arturo (Grayslake, IL, US); Carroll, William A. (Evanston, IL, US); Patel, Meena V. (Green Oaks, IL, US); Tietje, Karin Rosemarie (Mundelein, IL, US); Li, Tongmei (Lake Bluff, IL, US); Kolasa, Teodozyj (Lake Villa, IL, US); Gallagher, Megan E. (Highland Park, IL, US); Peddi, Sridhar (Grayslake, IL, US); Frost, Jennifer M. (Grayslake, IL, US); Nelson, Derek W. (Highland Park, IL, US) |
| Assignees: |
ABBOTT LABORATORIES (Abbott Park, IL, US) |
| Claim: |
1. A compound according to formula (I), [chemical expression included] or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof, wherein R1 is alkoxyalkyl, alkoxyalkoxyalkyl, hydroxyalkyl, A, or A-alkylene-; R2 is hydrogen, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkyl-S(O)2—, aryl, arylalkyl, arylalkenyl, azidoalkyl, cyano, cycloalkyl, halo, haloalkyl, heteroaryl, heterocycle, —(CR21R22)m—OH, RaRbN—, RaRbN-alkyl-, RcRdNC(O)—, or R8—R7—; R3 is hydrogen, alkoxy, alkoxyalkyl, alkyl, alkylcarbonyl, alkyl-S(O)2—, aryl, arylalkyl, arylalkenyl, cyano, cycloalkyl, halo, haloalkyl, heteroaryl, heterocycle, —(CR31R32)m—OH, RaRbN—, RaRbN-alkyl-, or R8—R7—; or R2 and R3, together with the carbon atoms to which they are attached, form a 4-, 5-, 6-, or 7-membered monocyclic ring, optionally fused to benzo or oxadiazole, said monocyclic ring contains zero or one additional double bond, zero or one oxygen atom, and zero or one nitrogen atom as ring atoms; two non-adjacent atoms of said monocyclic ring are optionally linked by an alkenylene bridge of 2, 3, or 4 carbon atoms, or optionally linked by an alkylene bridge of 1, 2, 3, or 4 carbon atoms, said monocyclic ring is independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents independently selected from the group consisting of oxo, alkyl, halo, —OH, —O(alkyl), and haloalkyl; two substituents on the same carbon atom of said monocyclic ring, together with the carbon atom to which they are attached, optionally form a 3-, 4-, 5-, or 6-membered monocyclic cycloalkyl ring, wherein the monocyclic cycloalkyl ring is optionally substituted with 1, 2, 3, 4, 5, or 6 substituents independently selected from the group consisting of alkyl and haloalkyl; with the proviso that when R2 and R3, together with the carbon atom to which they are attached, form a ring as represented by formula (viii), (ix), or (xi), [chemical expression included] then R1 is A or A-alkylene-; and with a further proviso that when R2 and R3 are other than forming a ring with the carbon atoms to which they are attached, then R1 is alkoxyalkoxyalkyl, A or A-alkylene-; R4 is alkyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocycle, cycloalkylalkyl, cycloalkenylalkyl, arylalkyl, heteroarylalkyl, heterocyclealkyl, or R10-L2-R9—; wherein the alkyl group is optionally substituted with one substituent selected from the group consisting of alkoxy, alkoxycarbonyl, carboxy, halo, —OH, and ReRfN—; R7, R8, and R9, are each independently aryl, cycloalkyl, cycloalkenyl, heteroaryl, or heterocycle; R10 is aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocycle, or cycloalkylalkyl; Ra and Rb, at each occurrence, are each independently hydrogen, alkoxycarbonyl, alkyl, alkylcarbonyl, alkyl-S(O)2—, or arylalkyl; Rc and Rd, are each independently hydrogen or alkyl; Re and Rf, are each independently hydrogen, alkyl, or alkylcarbonyl; A is a 4-, 5-, 6-, 7-, 8-, or 9-membered monocyclic heterocycle containing zero or one double bond, one or two oxygen, and zero or one nitrogen as ring atoms; two non-adjacent atoms of said heterocycle ring can be optionally linked by an alkenylene bridge of 2, 3, or 4 carbon atoms, or optionally linked by an alkylene bridge of 1, 2, 3, or 4 carbon atoms; or A is furanyl, oxazolyl, isoxazolyl, or oxadiazolyl; each ring A is optionally fused with a monocyclic ring selected from the group consisting of benzo, cycloalkyl, cycloalkenyl, heterocycle and heteroaryl; and each A is independently unsubstituted or substituted with 1, 2, 3, 4, 5, or 6 substituents independently selected from the group consisting of oxo, alkyl, halo, —OH, —O(alkyl), and haloalkyl; L1 is a single bond or —NRg—; L2 is a single bond, alkylene, or —O—; Rg is hydrogen or alkyl; the aryl, cycloalkyl, cycloalkenyl, heterocycle, or heteroaryl moieties, as a substituent, or as part of a substituent, as represented by R2, R3, R4, Ra, Rb, R7, R8, R9, and R10, are each independently unsubstituted or substituted with 1, 2, 3, 4, 5, or 6 substituents independently selected from the group consisting of alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkoxyalkyl, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkoxysulfonyl, alkyl, alkylcarbonyl, alkylcarbonylalkyl, alkylcarbonyloxy, alkylsulfinyl, alkylsulfinylalkyl, alkyl-S(O)2—, alkyl-S(O)2—(CR41R42)p═C(R41)—, alkyl-S(O)2—(CR41R42)p—, alkyl-S—, alkyl-S—(CR41R42)p—, alkynyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, formyl, formylalkyl, halogen, haloalkyl, haloalkoxy, hydroxy, hydroxyalkyl, oxo, —SH, N(O)2, —C(R41)═N—O(R42), —(CR41R42)p—C(R41)═N—O(R42), ═N—O(alkyl), ═N—OH, NZ1Z2—(CR41R42)p—O—, —O—(CR41R42)p-G1, G1, —NZ1Z2, —(CR41R42)p—NZ1Z2, and (NZ3Z4)carbonyl; G1 is a 4-, 5-, 6-, or 7-membered monocyclic heterocycle containing one nitrogen atom and optionally 1 or 2 additional heteroatom in the ring, wherein said ring is attached to the parent moiety through the nitrogen atom, and said ring is optionally substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of alkyl, alkenyl, alkynyl, halo, haloalkyl, ═N—CN, ═N—OR51, —CN, oxo, —OR51, —OC(O)R51, —OC(O)N(R51)2, —S(O)2R52, —S(O)2N(R51)2, —C(O)R51, —C(O)OR51, —C(O)N(R51)2, —N(R51)2, —N(R51)C(O)R51, —N(R51)S(O)2R52, —N(R51)C(O)O(R52), —N(R51)C(O)N(R51)2, —(CR1cR1d)q—OR51, —(CR1cR1d)q—OC(O)R51, —(CR1cR1d)q—OC(O)N(R51)2, —(CR1cR1d)q—S(O)2R52, —(CR1cR1d)q—S(O)2N(R51)2, —(CR1cR1d)q—C(O)R51, —(CR1cR1d)q—C(O)OR51, —(CR1cR1d)q—C(O)N(R51)2, —(CR1cR1d)q—N(R51)2, —(CR1cR1d)q—N(R51)C(O)R51, —(CR1cR1d)q—N(R51)S(O)2R52, —(CR1cR1d)q—N(R51)C(O)O(R52), —(CR1cR1d)q—N(R51)C(O)N(R51)2, and —(CR1cR1d)q—CN; R51, at each occurrence, is independently hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, —(CR2cR2d)u—OR53, monocyclic cycloalkyl, or —(CR2cR2d)u-(monocyclic cycloalkyl); wherein R53 is hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, monocyclic cycloalkyl, or —(CR2cR2d)u-(monocyclic cycloalkyl); R52, at each occurrence, is independently C1-C4 alkyl, C1-C4 haloalkyl, monocyclic cycloalkyl, or —(CR2cR2d)u-(monocyclic cycloalkyl); the monocyclic cycloalkyl moiety, as a substituent, or as part of a substituent, as represented by R51, R52, and R53 are each independently unsubstituted or substituted with 1, 2, 3, or 4 substituents selected from the group consisting of C1-C4 alkyl, halo, hydroxy, C1-C4 alkoxy, C1-C4 haloalkoxy, and C1-C4 haloalkyl; R21, R22, R31, R32, R41, R42, R1c, R1d, R2c, and R2d, at each occurrence, are each independently hydrogen, alkyl, haloalkyl, or halo; m, p, q, and u, at each occurrence, are each independently 1, 2, 3, or 4; Z1 and Z2 are each independently hydrogen, alkyl, alkoxyalkyl, alkylcarbonyl, cyanoalkyl, haloalkyl, or formyl; and Z3 and Z4 are each independently hydrogen, alkyl, haloalkyl, phenyl or benzyl wherein the phenyl moiety is optionally substituted with 1, 2, 3, or 4 substituents selected from the group consisting of alkyl, hydroxyl, and haloalkyl. |
| Claim: |
2. The compound of claim 1, or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof, wherein R1 is A or A-alkylene- and A is a 4-, 5-, 6-, 7-, 8-, or 9-membered monocyclic heterocycle containing zero or one double bond, one or two oxygen, and zero or one nitrogen as ring atoms; two non-adjacent atoms of said heterocycle ring can be optionally linked by an alkenylene bridge of 2, 3, or 4 carbon atoms, or optionally linked by an alkylene bridge of 1, 2, 3, or 4 carbon atoms; each ring A is optionally fused with a monocyclic ring selected from the group consisting of benzo, cycloalkyl, cycloalkenyl, heterocycle, and heteroaryl; and each A is independently unsubstituted or substituted with 1, 2, 3, 4, 5, or 6 substituents independently selected from the group consisting of oxo, alkyl, halo, —OH, —O(alkyl), and haloalkyl. |
| Claim: |
3. The compound of claim 2, or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof, wherein R2 is hydrogen, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, aryl, halo, haloalkyl, or —(CR21R22)m—OH; R3 is hydrogen, alkyl, alkylcarbonyl, aryl, cycloalkyl, halo, haloalkyl, heterocycle, or —(CR31R32)m—OH; L1 is a bond; and R4 is aryl, heteroaryl, cycloalkyl, heterocycle, arylalkyl, heteroarylalkyl, heterocyclealkyl, cycloalkylalkyl, R10-L2-R9—, alkynyl, or alkyl; wherein the alkyl is optionally substituted with one substituent selected from the group consisting of alkoxycarbonyl, —OH, or ReRfN—. |
| Claim: |
4. The compound of claim 3, or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof, wherein R4 is optionally substituted phenyl or R10L2-R9—; L2 is O; and R9 is optionally substituted aryl. |
| Claim: |
5. The compound of claim 2, or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof, wherein R2 is hydrogen or alkyl; R3 is alkyl or —(CR31R32)m—OH; L1 is a bond; R4 is optionally substituted phenyl or R10L2-R9—; L2 is O; and R9 is optionally substituted aryl. |
| Claim: |
6. The compound of claim 3, or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof, wherein R4 is optionally substituted phenyl or R10-L2-R9—; L2 is alkyene; and R9 is optionally substituted aryl. |
| Claim: |
7. The compound of claim 2, or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof, wherein R2 is hydrogen, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, aryl, halo, haloalkyl, or —(CR21R22)m—OH; R3 is hydrogen, alkyl, alkylcarbonyl, aryl, cycloalkyl, halo, haloalkyl, heterocycle, or —(CR31R32)m—OH; L1 is a NRg; and R4 is arylalkyl, cyclolalkyl, cycloalkylalkyl, or alkyl; wherein the alkyl is optionally substituted with one substituent selected from the group consisting of alkoxycarbonyl, —OH, or ReRfN—. |
| Claim: |
8. The compound of claim 1, or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof, wherein R1 is A-alkylene- and A is furanyl, oxazolyl, isoxazolyl, or oxadiazolyl, each of which is optionally substituted. |
| Claim: |
9. The compound of claim 8, or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof, wherein R2 is hydrogen, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, aryl, halo, haloalkyl, or —(CR21R22)m—OH; R3 is hydrogen, alkyl, alkylcarbonyl, aryl, cycloalkyl, halo, haloalkyl, heterocycle, or —(CR31R32)m—OH; L1 is a bond; and R4 is aryl, heteroaryl, cycloalkyl, heterocycle, arylalkyl, heteroarylalkyl, heterocyclealkyl, cycloalkylalkyl, R10-L2-R9—, alkynyl, or alkyl; wherein the alkyl is optionally substituted with one substituent selected from the group consisting of alkoxycarbonyl, —OH, or ReRfN—. |
| Claim: |
10. The compound of claim 8, or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof, wherein R2 is hydrogen or alkyl; R3 is alkyl or —(CR31R32)m—OH; L1 is a bond; R4 is optionally substituted phenyl or R10-L2-R9—; L2 is O; and R9 is optionally substituted aryl. |
| Claim: |
11. The compound of claim 8, or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof, wherein R2 is hydrogen, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, aryl, halo, haloalkyl, or —(CR21R22)m—OH; R3 is hydrogen, alkyl, alkylcarbonyl, aryl, cycloalkyl, halo, haloalkyl, heterocycle, or —(CR31R32)m—OH; L1 is a NRg; and R4 is arylalkyl, cyclolalkyl, cycloalkylalkyl, or alkyl; wherein the alkyl is optionally substituted with one substituent selected from the group consisting of alkoxycarbonyl, —OH, or ReRfN—. |
| Claim: |
12. The compound of claim 1, or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof, wherein R2 and R3, together with the carbon atoms to which they are attached, form a 4-, 5-, 6-, or 7-membered monocyclic ring optionally fused to benzo or oxadiazole, said monocyclic ring contains zero or one additional double bond, zero oxygen atom and zero nitrogen atom as ring atoms; two non-adjacent atoms of said monocyclic ring are linked by an alkenylene bridge of 2, 3, or 4 carbon atoms, or linked by an alkylene bridge of 1, 2, 3, or 4 carbon atoms, said monocyclic ring is independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents independently selected from the group consisting of oxo, alkyl, halo, —OH, —O(alkyl), and haloalkyl; two substituents on the same carbon atom of said monocyclic ring, together with the carbon atom to which they are attached, optionally form a 3-, 4-, 5-, or 6-membered monocyclic cycloalkyl ring, wherein the monocyclic cycloalkyl ring is optionally substituted with 1, 2, 3, 4, 5, or 6 substituents independently selected from the group consisting of alkyl and haloalkyl. |
| Claim: |
13. The compound of claim 12, or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof, wherein R4 is aryl, heteroaryl, cycloalkyl, heterocycle, arylalkyl, heteroarylalkyl, heterocyclealkyl, cycloalkylalkyl, R10-L2-R9—, alkynyl, or alkyl; wherein the alkyl is optionally substituted with one substituent selected from the group consisting of alkoxycarbonyl, —OH, or ReRfN—. |
| Claim: |
14. The compound of claim 1, or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof, wherein R2 and R3, together with the carbon atoms to which they are attached, form an optionally substituted ring as represented by [chemical expression included] |
| Claim: |
15. The compound of claim 1, or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof, wherein R2 and R3, together with the carbon atoms to which they are attached, form a 4-, 5-, 6-, or 7-membered monocyclic ring optionally fused to benzo or oxadiazole, said monocyclic ring contains zero or one additional double bond, and one oxygen atom and zero or one nitrogen atom as ring atoms; two non-adjacent atoms of said monocyclic ring can be optionally linked by an alkenylene bridge of 2, 3, or 4 carbon atoms, or optionally linked by an alkylene bridge of 1, 2, 3, or 4 carbon atoms, said monocyclic ring is independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents independently selected from the group consisting of oxo, alkyl, halo, —OH, —O(alkyl), and haloalkyl; two substituents on the same carbon atom of said monocyclic ring, together with the carbon atom to which they are attached, optionally form a 3-, 4-, 5-, or 6-membered monocyclic cycloalkyl ring, wherein the monocyclic cycloalkyl ring is optionally substituted with 1, 2, 3, 4, 5, or 6 substituents independently selected from the group consisting of alkyl and haloalkyl. |
| Claim: |
16. The compound of claim 15, or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof, wherein R4 is aryl, heteroaryl, cycloalkyl, heterocycle, arylalkyl, heteroarylalkyl, heterocyclealkyl, cycloalkylalkyl, R10-L2-R9—, alkynyl, or alkyl; wherein the alkyl is optionally substituted with one substituent selected from the group consisting of alkoxycarbonyl, —OH, or ReRfN—. |
| Claim: |
17. The compound of claim 1, or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof, wherein R2 and R3, together with the carbon atoms to which they are attached, form a ring as represented by [chemical expression included] and R1 is A or A-alkylene-. |
| Claim: |
18. The compound of claim 1 selected from the group consisting of N-[(7Z)-8-(2-methoxyethyl)-5,8-dihydro[1,3]thiazolo[4,5-e][2,1,3]benzoxadiazol-7(4H)-ylidene]-2,2,3,3-tetramethylcyclopropanecarboxamide; N-[(7Z)-8-(2-methoxyethyl)[1,3]thiazolo[4,5-e][2,1,3]benzoxadiazol-7(8H)-ylidene]-2,2,3,3-tetramethylcyclopropanecarboxamide; 2-Ethoxy-N-[(2Z)-3-(2-methoxyethyl)-4,6-dihydrofuro[3,4-d]thiazol-2(3H)-ylidene]-benzamide; 2,3-dichloro-N-[(2Z)-5-methyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]benzamide; 2,3-dichloro-N-[(2Z)-5-methyl-3-(tetrahydro-2H-pyran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]benzamide; 2-ethoxy-N-[(2Z)-5-methyl-3-(tetrahydro-2H-pyran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]benzamide; 5-chloro-2-methoxy-N-[(2Z)-5-methyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]benzamide; 5-chloro-2-methoxy-N-[(2Z)-5-methyl-3-(tetrahydro-2H-pyran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]benzamide; 2-ethoxy-N-[(2Z)-5-methyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]benzamide; 5-chloro-2-methoxy-N-[(2Z)-5-methyl-3-(tetrahydrofuran-3-ylmethyl)-1,3-thiazol-2(3H)-ylidene]benzamide; 2-ethoxy-N-[(2Z)-5-methyl-3-(tetrahydrofuran-3-ylmethyl)-1,3-thiazol-2(3H)-ylidene]benzamide; 2-ethoxy-N-[(2Z)-3-[2-(2-methoxyethoxy)ethyl]-5-methyl-1,3-thiazol-2(3H)-ylidene]benzamide; 2,3-dichloro-N-[(2Z)-3-[2-(2-methoxyethoxy)ethyl]-5-methyl-1,3-thiazol-2(3H)-ylidene]benzamide; 5-chloro-2-methoxy-N-[(2Z)-3-[2-(2-methoxyethoxy)ethyl]-5-methyl-1,3-thiazol-2(3H)-ylidene]benzamide; 2-methoxy-N-[(2Z)-5-methyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]benzamide; 1-(1,1-dimethylpropyl)-3-[(2Z)-5-methyl-3-(tetrahydropyran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]urea; 1-(1,2-dimethyl-propyl)-3-[(2Z)-5-methyl-3-(tetrahydropyran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]urea hydrochloride; 1-cyclohexyl-3-[(2Z)-4,5-dimethyl-3-(tetrahydropyran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]urea; 1-(4-methylcyclohexyl)-3-[(2Z)-5-methyl-3-(tetrahydropyran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]urea; 1-(1,1-dimethylpropyl)-3-[(2Z)-34 tetrahydropyran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]urea; N-[(2Z)-4,5-dimethyl-3-(tetrahydro-2H-pyran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-N′-[(1S)-1,2,2-trimethylpropyl]urea; 1-(2,2-dimethylpropyl)-3-[(2Z)-4,5-dimethyl-3-(tetrahydropyran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]urea; N-[(2Z)-3-(tetrahydro-2H-pyran-2-ylmethyl)-1,3-thiazol-2(31/)-ylidene]-N′-[(1S)-1,2,2-trimethylpropyl]urea; N-[(2Z)-5-methyl-3-(tetrahydro-2H-pyran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-N′-[(1S)-1,2,2-trimethylpropyl]urea; 1-(4-methylcyclohexyl)-3-[(2Z)-4,5-dimethyl-3-(tetrahydropyran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]urea; 1-(2,2-dimethylpropyl)-3-[(2Z)-5-methyl-3-(tetrahydropyran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]urea; 1-tert-butyl-3-[(2Z)-4,5-dimethyl-3-(tetrahydropyran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]urea; 1-(1,1-dimethylpropyl)-3-[(2Z)-4,5-dimethyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]urea; 1-(2,2-dimethylpropyl)-3-[(2Z)-4,5-dimethyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]urea; 1-[(2Z)-4,5-dimethyl-3-(tetrahydropyran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-3-(3,3,5,5-tetramethylcyclohexyl)urea; N-[(2Z)-4,5-dimethyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-N′-[(1S) -1,2,2-trimethylpropyl]urea; N-[(2Z)-4,5-dimethyl-3-(tetrahydro-2H-pyran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-N′-[(1R)-1,2,2-trimethylpropyl]urea; 1-tert-butyl-3-[(2Z)-5-methyl-3-(tetrahydropyran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]urea; 1-(2,3-dichlorophenyl)-3-[(2Z)-4,5-dimethyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]urea; N-[(2Z)-4,5-dimethyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-N′-[(1R) -1,2,2-trimethylpropyl]urea; N-[(1S) -1,2-dimethylpropyl]-N′-[(2Z)-4,5-dimethyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]urea; 1-(1-cyclopropylethyl)-3-[(2Z)-4,5-dimethyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]urea; 2-ethoxy-N-[(2Z)-5-methyl-3-(tetrahydro-2H-pyran-4-ylmethyl)-1,3-thiazol-2(3H)-ylidene]benzamide; 2,4-dimethoxy-N-[(2Z)-5-methyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]benzamide; 5-chloro-2-methoxy-N-[(2Z)-4-methyl-3-(tetrahydro-2H-pyran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]benzamide; 5-chloro-2-methoxy-N-[(2Z)-5-methyl-3-(tetrahydro-2H-pyran-4-ylmethyl)-1,3-thiazol-2(3H)-ylidene]benzamide; 5-chloro-2-methoxy-N-[(2Z)-3-(tetrahydro-2H-pyran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]benzamide; 5-chloro-2-methoxy-N-[(2Z)-5-methyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]benzamide; 5-chloro-2-methoxy-N-[(2Z)-5-methyl-3-[(2S)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]benzamide; 2,2,3,3-tetrafluoro-1-methyl-N-[(2Z)-5-methyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]cyclobutanecarboxamide; 5-chloro-2-methoxy-N-[(2Z)-5-methyl-3-(oxetan-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]benzamide; 5-chloro-N-[(2Z)-3-(1,3-dioxolan-2-ylmethyl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide; 5-chloro-N-[(2Z)-3-[2-(1,3-dioxolan-2-yl)ethyl]-5-methyl-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide; N-[(2Z)-3-(1,3-dioxolan-2-ylmethyl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-2-ethoxybenzamide; 5-bromo-2-ethoxy-N-[(2Z)-5-methyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]benzamide; 5-chloro-2-ethoxy-N-[(2Z)-5-methyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]benzamide; 4-chloro-2-methoxy-N-[(2Z)-5-methyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]benzamide; 5-chloro-2-methoxy-N-[(2Z)-1-(2-methoxyethyl)-1,4,6,7-tetrahydro-2H-pyrano[4,3-d][1,3]thiazol-2-ylidene]benzamide; 5-bromo-2-methoxy-N-[(2Z)-5-methyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]benzamide; 5-chloro-2-methoxy-N-[(2Z)-5-methyl-3-(2-tetrahydro-2H-pyran-4-ylethyl)-1,3-thiazol-2(3H)-ylidene]benzamide; 5-chloro-N-[(2Z)-5-ethyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide; 5-chloro-2-methoxy-N-[(2Z)-5-propyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]benzamide; 5-chloro-N-[(2Z)-5-chloro-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide; 4,5-dichloro-2-methoxy-N-[(2Z)-5-methyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]benzamide; 5-chloro-2-methoxy-N-[(2Z)-5-methyl-3-(tetrahydro-2H-pyran-3-ylmethyl)-1,3-thiazol-2(3H)-ylidene]benzamide; 2-chloro-N-[(2Z)-4,5-dimethyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]nicotinamide; 5-chloro-N-[(2Z)-4,5-dimethyl-3-[(3-methyl-4,5-dihydroisoxazol-5-yl)methyl]-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide; N-[(2Z)-4,5-dimethyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-4-(trifluoromethyl)nicotinamide; N-[(2Z)-4,5-dimethyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-2-ethoxynicotinamide; N-[(2Z)-4,5-dimethyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-2,3,6-trifluoroisonicotinamide; 6-chloro-N-[(2Z)-4,5-dimethyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-4-(trifluoromethyl)nicotinamide; 5-chloro-2-methoxy-N-[(2Z)-5-methyl-3-[(3-methyl-4,5-dihydroisoxazol-5-yl)methyl]-1,3-thiazol-2(3H)-ylidene]benzamide; N-[(2Z)-4,5-dimethyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-2-(ethylamino)benzamide; N-[(2Z)-4,5-dimethyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-5-iodo-2-(methylamino)benzamide; 5-bromo-N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide; 5-chloro-2-(cyclopropyloxy)-N-[(2Z)-5-methyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]benzamide; 5-chloro-N-[(2Z)-3-(1,4-dioxan-2-ylmethyl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide; N-[(2Z)-5-acetyl-4-methyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; 5-chloro-N-[(2Z)-5-(1-hydroxy-1-methylethyl)-4-methyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; N-[(2Z)-5-tert-butyl-3-(1,3-dioxolan-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; 5-chloro-N-[(2Z)-5-chloro-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide; 5-chloro-N-[(2Z)-5-chloro-3-(tetrahydro-2H-pyran-4-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide; N-[(2Z)-5-tert-butyl-3-[(3-methyl-4,5-dihydroisoxazol-5-yl)methyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2,2-dimethyl-4-oxo-3,4-dihydro-2H-pyran-6-carboxamide; N-[(2Z)-5-tert-butyl-3-(tetrahydro-2H-pyran-4-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; 5-chloro-2-methoxy-N-[(2Z)-3-(tetrahydro-2H-pyran-4-ylmethyl)-4,5,6,7-tetrahydro-1,3-benzothiazol-2(3H)-ylidene]benzamide; 5-chloro-2-methoxy-N-[(2Z)-3-(2-methoxyethyl)-4,4,6,6-tetramethyl-4,6-dihydrofuro[3,4-d][1,3]thiazol-2(3H)-ylidene]benzamide; 5-chloro-2-methoxy-N-[(2Z)-3-(2-methoxyethyl)-6,6-dimethyl-4-oxo-4,6-dihydrofuro[3,4-d][1,3]thiazol-2(3H)-ylidene]benzamide; N-[(2Z)-5-acetyl-4-methyl-3-(oxetan-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; 5-chloro-N-[(2Z)-4,4-dimethyl-1-(oxetan-2-ylmethyl)-1,4,6,7-tetrahydro-2H-pyrano[4,3-d][1,3]thiazol-2-ylidene]-2-methoxybenzamide; 5-chloro-N-{(2Z)-4,4-dimethyl-1-[(2R)-tetrahydro furan-2-ylmethyl]-1,4,6,7-tetrahydro-2H-pyrano[4,3-d][1,3]thiazol-2-ylidene]-2-methoxybenzamide; N-[(2Z)-5-acetyl-4-methyl-3-(tetrahydro-2H-pyran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; N-[(2Z)-5-acetyl-4-methyl-3-(tetrahydro-2H-pyran-3-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; 5-chloro-N-[(2Z)-5-(1-hydroxy-1-methylethyl)-4-methyl-3-(tetrahydro-2H-pyran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide; 5-chloro-2-methoxy-N-[(2Z)-4-methyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2(3H)-ylidene]benzamide; 5-chloro-N-[(2Z)-5-(1-hydroxy-1-methylethyl)-4-methyl-3-(tetrahydro-2H-pyran-3-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide; 5-chloro-N-[(2Z)-3-{[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}-5-(1-hydroxy-1-methylethyl)-4-methyl-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide; 5-chloro-N-[(2Z)-6,6-dimethyl-4-oxo-3-[(2R)-tetrahydrofuran-2-ylmethyl]-4,6-dihydrofuro[3,4-d][1,3]thiazol-2(3H)-ylidene]-2-methoxybenzamide; 5-chloro-N-[(2Z)-3-{[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}-5-(1-hydroxy-1-methylethyl)-4-methyl-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide; N-[(2Z)-5-acetyl-3-(1,4-dioxan-2-ylmethyl)-4-methyl-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; 5-chloro-N-[(2Z)-5-(1-hydroxy-1-methylethyl)-4-methyl-3-(oxetan-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide; 5-chloro-N-[(2Z)-5-(1-hydroxy-1-methylethyl)-4-methyl-3-(tetrahydrofuran-3-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide; 5-chloro-N-[(2Z)-3-(1,4-dioxan-2-ylmethyl)-54 1-hydroxy-1-methylethyl)-4-methyl-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-3-methoxy-2-naphthamide; N-[(2Z)-5-tert-butyl-3-[(3-methyloxetan-3-yl)methyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; 5-chloro-2-methoxy-N-[(2Z)-3-(tetrahydrofuran-2-ylmethyl)-3,4,5,6-tetrahydro-2H-cyclopenta[d][1,3]thiazol-2-ylidene]benzamide; 5-chloro-2-methoxy-N-[(2Z)-3-(tetrahydro-2H-pyran-4-ylmethyl)-3,4,5,6-tetrahydro-2H-cyclopenta[d][1,3]thiazol-2-ylidene]benzamide; N-[(2Z)-4,5-dimethyl-3-(tetrahydro-2H-pyran-4-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-2,2-dimethyltetrahydro-2H-pyran-4-carboxamide; N-[(2Z)-5-tert-butyl-3-(oxetan-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzarnide; N-[(2Z)-5-tert-butyl-3-(tetrahydro-2H-pyran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; N-[(2Z)-5-tert-butyl-3-(1,4-dioxan-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; N-[(2Z)-5-tert-butyl-3-{[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; N-[(2Z)-5-tert-butyl-3-{[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; N-[(2Z)-5-tert-butyl-3-(tetrahydrofuran-3-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; N-[(2Z)-5-tert-butyl-3-(tetrahydro-2H-pyran-3-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; N-[(2Z)-5-tert-butyl-3-{[(2S)-5-oxotetrahydrofuran-2-yl]methyl}-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; N-[(2Z)-5-acetyl-4-methyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-1-benzofuran-5-carboxamide; N-[(2Z)-5-(1-hydroxy-1-methylethyl)-4-methyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-1-benzofuran-5-carboxamide; N-[(2Z)-5-acetyl-4-methyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-(2,2,2-trifluoroethoxy)benzamide; N-[(2Z)-5-tert-butyl-3-[(5-methyltetrahydrofuran-2-yl)methyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; N-[(2Z)-5-tert-butyl-3-[(5,5-dimethyltetrahydrofuran-2-yl)methyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-(2-methoxyethoxy)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-6-chloroquinoline-8-carboxamide; 5-chloro-2-methoxy-N-[(2Z)-5-(1-methylcyclopropyl)-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]benzamide; 5-chloro-N-[(2Z)-5-(1-hydroxy-3-iodo-1-methylpropyl)-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-[(1-methylcyclopropyl)methoxy]benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-isopropoxybenzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-ethoxybenzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-(tetrahydrofuran-3-yloxy)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-[(2-methoxyethyl)(methyl)amino]benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-(difluoromethoxy)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-(trifluoromethoxy)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-(2,2,2-trifluoroethoxy)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-[3-(dimethylamino)propoxy]benzamide; 5,6-dichloro-N-[(2Z)-4,5-dimethyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]quinoline-8-carboxamide; 6-chloro-N-[(2Z)-4,5-dimethyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]quinoline-8-carboxamide; 6-chloro-N-[(2Z)-5-methyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]quinoline-8-carboxamide; 5,6-dichloro-N-[(2Z)-5-methyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]quinoline-8-carboxamide; 3-methoxy-N-[(2Z)-5-methyl-3-(tetrahydrofuran-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-2-naphthamide; N-[(2Z)-5-tert-butyl-3-[2-(2-methoxyethoxy)ethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; N-[(2Z)-5-tert-butyl-3-[(2S)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; 5-chloro-2-methoxy-N-[(2Z)-4,4,6,6-tetramethyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-4,6-dihydrofuro[3,4-d][1,3]thiazol-2(3H)-ylidene]benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-cyano-2-methoxybenzamide; N-[(2Z)-4-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; N-[(2Z)-5-tert-butyl-4-methyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; 5-chloro-2-methoxy-N-{(2Z)-3-[(2R)-tetrahydrofuran-2-ylmethyl]-3,4,5,6,7,8-hexahydro-2H-4,7-epoxycyclohepta[d][1,3]thiazol-2-ylidene}benzamide; 5-chloro-2-methoxy-N-[(2Z)-3-[(2R)-tetrahydrofuran-2-ylmethyl]-6,7-dihydro-4H-pyrano[3,4-d][1,3]thiazol-2(3H)-ylidene]benzamide; 5-chloro-2-methoxy-N-{(2Z)-1-[(2R)-tetrahydrofuran-2-ylmethyl]-1,4,6,7-tetrahydro-2H-pyrano[4,3-d][1,3]thiazol-2-ylidene}benzamide; N-[(2Z)-5-tert-butyl-3-(2-morpholin-4-ylethyl)-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-hydroxybenzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-methoxy-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-tetrahydro-2H-pyran-4-yl-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; N-[(2Z)-5-tert-butyl-3-{2-[cis-2,6-dimethylmorpholin-4-yl]ethyl}-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; N-[(2Z)-5-tert-butyl-3-{[(2R)-5-oxotetrahydrofuran-2-yl]methyl}-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; 5-chloro-N-[(2Z)-5-(1-hydroxy-1-methylethyl)-4-methyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-(2,2,2-trifluoroethoxy)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-[(E)-(hydroxyimino)methyl]benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-formylbenzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-N′-(1,1-dimethylpropyl)urea; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-N′-(1-methyl-1-phenylethyl)urea; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-N′-(2-hydroxy-1,1-dimethylethyl)urea; methyl N-({[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]amino}carbonyl)-2-methylalaninate; N-[(2Z)-5-tert-butyl-3-(1,3-oxazol-2-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; N-[(2Z)-5-tert-butyl-3-(1,2,4-oxadiazol-3-ylmethyl)-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; N-[(2Z)-5-tert-butyl-3-(2-furylmethyl)-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; 5-chloro-N-[(2Z)-4,5-dimethyl-3-[(3-methylisoxazol-5-yl)methyl]-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide; 5-chloro-2-methoxy-N-[(2Z)-5-methyl-3-{[5-(trifluoromethyl)-2-furyl]methyl}-1,3-thiazol-2(3H)-ylidene]benzamide; 5-chloro-N-[(2Z)-3-(2-furylmethyl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide; 5-chloro-N-[(2Z)-3-(3-furylmethyl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-ethoxy-5-(trifluoromethyl)benzamide; 5-chloro-2-methoxy-N-[(2Z)-5-methyl-3-(2-morpholin-4-ylethyl)-1,3-thiazol-2(3H)-ylidene]benzamide; N-[(2Z)-5-tert-butyl-3-{[(4S)-2-oxo-1,3-oxazolidin-4-yl]methyl}-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; 2-[(1-aminocyclopentyl)methoxy]-N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-{[(3S)-1-(2-oxopropyl)pyrrolidin-3-yl]oxy}-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-{[1-(2-oxopropyl)azetidin-3-yl]oxy}-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-({1-[2-(hydroxyimino)propyl]azetidin-3-yl}oxy)-5-(trifluoromethyl)benzamide; 5-chloro-2-(4-chlorophenoxy)-N-[(2Z)-3-(2-methoxyethyl)-5-methyl-1,3-thiazol-2(3H)-ylidene]benzamide; 5-chloro-N-[(2Z)-3-(2-methoxyethyl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-2-(tetrahydrofuran-3-yloxy)benzamide; N-[(2Z)-5-tert-butyl-4-methyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-fluoro-3-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-[2-(dimethylamino)ethoxy]-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-[2-(dimethylamino)-2-methylpropoxy]-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-(2-morpholin-4-ylethoxy)-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-[2-(diethylamino)ethoxy]-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-[2-(1,1-dioxidothiomorpholin-4-yl)ethoxy]-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-(2-piperidin-1-ylethoxy)-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-(3-methoxy-3-methylbutoxy)-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-[2-(2-oxopyrrolidin-1-yl)ethoxy]-5-(trifluoromethyl)benzamide; 1-benzyl-3-tert-butyl-N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-1H-pyrazole-5-carboxamide; methyl 2-({[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)benzoate; 3-tert-butyl-N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-1-methyl-1H-pyrazole-5-carboxamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; 2-[2-(tert-butylamino)ethoxy]-N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-(trifluoromethyl)benzamide; tert-butyl 3-{[3-tert-butyl-5-({[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]amino}carbonyl)-1H-pyrazol-1-yl]methyl}azetidine-1-carboxylate; 1-(azetidin-3-ylmethyl)-3-tert-butyl-N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-1H-pyrazole-5-carboxamide; N-[(2Z)-5-tert-butyl-3-[(5-methylisoxazol-3-yl)methyl]-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-({(3S)-1-[2-(hydroxyimino)propyl]pyrrolidin-3-yl}oxy)-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-(2-hydroxyethyl)-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; 5-chloro-N-[(2Z)-5-(4,4-difluorocyclohexyl)-3-(2-methoxyethyl)-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-cyano-5-(trifluoromethyl)benzamide; 2-tert-butoxy-N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-{[(3R)-1-methylpyrrolidin-3-yl]oxy}-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-{[(3S)-1-methylpyrrolidin-3-yl]oxy}-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-formyl-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-3-(trifluoromethyl)benzamide; 2-(azetidin-1-ylmethyl)-N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-(pyrrolidin-1-ylmethyl)-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-{[(3S)-3-hydroxypyrrolidin-1-yl]methyl}-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-methyl-5-(trifluoromethyl)benzamide; 2-(azetidin-3-yloxy)-N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-[(1-methylazetidin-3-yl)oxy]-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-[(3R)-pyrrolidin-3-yloxy]-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-[(3S)-pyrrolidin-3-yloxy]-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-(trifluoromethyl)-2-vinylbenzamide; tert-butyl 4-[2-({[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenyl]-3,6-dihydropyridine-1(2H)-carboxylate; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-(1,2,3,6-tetrahydropyridin-4-yl)-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-ethyl-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-[(E)-2-(methylsulfonyl)vinyl]-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-[2-(methylsulfonyl)ethyl]-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-{[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]methyl}-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-(morpholin-4-ylmethyl)-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-(thiomorpholin-4-ylmethyl)-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-{[(cyanomethyl)(methyl)amino]methyl}-5-(trifluoromethyl)benzamide; N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-{[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]methyl}-5-(trifluoromethyl)benzamide; and 2-[(tert-butylamino)methyl]-N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-5-(trifluoromethyl)benzamide; or a pharmaceutical acceptable salt thereof. |
| Claim: |
19. A compound of formula (II), or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof [chemical expression included] wherein R1a is alkoxyalkyl, hydroxyalkyl, alkyl, haloalkyl, or cycloalkylalkyl wherein the cycloalkyl moiety is optionally substituted with 1, 2, 3, 4, 5, or 6 substituents independently selected from the group consisting of oxo, alkyl, halo, —OH, —O(alkyl), and haloalkyl; R2a is hydrogen or alkyl; Rx is an optional substituent of phenyl, selected from the group consisting of alkyl, alkylcarbonyl, alkoxy, alkoxyalkoxy, cyano, formyl, halogen, haloalkoxy, hydroxy, hydroxyalkyl, haloalkyl, ═N—OH, NZ1aZ2a—(CR41aR42a)v—O—, —O—(CR41aR42a)v-G1a, —(CR41aR42a)v-G1a, —(CR41aR42a)v—NZ1aZ2a, and NZ1aZ2a; G1a is a 4-, 5-, 6-, or 7-membered monocyclic heterocycle containing one nitrogen atom and optionally 1 or 2 additional heteroatom in the ring, wherein said ring is attached to the parent moiety through the nitrogen atom, and said ring is optionally substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of alkyl, alkenyl, alkynyl, halo, haloalkyl, ═N—CN, ═N—OR51a, —CN, oxo, —OR51a, —OC(O)R51a, —OC(O)N(R51a)2, —S(O)2R52a, —S(O)2N(R51a)2, —C(O)R51a, —C(O)OR51a, —C(O)N(R51a)2, —N(R51a)2, —N(R51a)C(O)R51a, —N(R51a)S(O)2R52a, —N(R51a)C(O)O(R52a), —N(R51a)C(O)N(R51a)2, —(CR1eR1f)w—OR51, —(CR1eR1f)w—OC(O)R51a, —(CR1eR1f)w—OC(O)N(R51a)2, —(CR1eR1f)w—S(O)2R52a, —(CR1eR1f)w—S(O)2N(R51a)2, —(CR1eR1f)w—C(O)R51a, —(CR1eR1f)w—C(O)OR51a, —(CR1eR1f)w—C(O)N(R51a)2, —(CR1eR1f)w—N(R51a)2, —(CR1eR1f)w—N(R51a)C(O)R51a, —(CR1eR1f)w—N(R51a)S(O)2R52a, —(CR1eR1f)w—N(R51a)C(O)O(R52a), —(CR1eR1f)w—N(R51a)C(O)N(R51a)2, and —(CR1eR1f)w—CN; R51a, at each occurrence, is independently hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, —(CR2eR2f)y—OR53, monocyclic cycloalkyl, or —(CR2eR2f)y-(monocyclic cycloalkyl); wherein R53a is hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, monocyclic cycloalkyl, or —(CR2eR2f)y-(monocyclic cycloalkyl); R52a, at each occurrence, is independently C1-C4 alkyl, C1-C4 haloalkyl, monocyclic cycloalkyl, or —(CR2eR2f)y-(monocyclic cycloalkyl); the monocyclic cycloalkyl moiety, as a substituent, or as part of a substituent, as represented by R51a, R52a, and R53a are each independently unsubstituted or substituted with 1, 2, 3, or 4 substituents selected from the group consisting of C1-C4 alkyl, halo, hydroxy, C1-C4 alkoxy, C1-C4 haloalkoxy, and C1-C4 haloalkyl; R41a, R42a, R1e, R1f, R2e, and R2f, at each occurrence, are each independently hydrogen, alkyl, haloalkyl, or halo; v, w, and y, at each occurrence, are each independently 1, 2, 3, or 4; Z1a and Z2a are each independently hydrogen, alkyl, alkoxyalkyl, alkylcarbonyl, cyanoalkyl, haloalkyl, or formyl; and n is 1, 2, 3, 4, or 5. |
| Claim: |
20. The compound of claim 19, or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof, wherein R1a is cyclobutylmethyl. |
| Claim: |
21. The compound of claim 19, or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof, wherein R1a is alkyl or alkoxyalkyl. |
| Claim: |
22. The compound of claim 19 selected from the group consisting of 5-chloro-N-[(2Z)-5-(1-hydroxy-1-methylethyl)-3-[((cis)-3-methoxycyclobutyl)methyl]-4-methyl-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide, 5-chloro-N-[(2Z)-5-(1-hydroxy-1-methylethyl)-3-(2-methoxyethyl)-4-methyl-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide; N-[(2Z)-3-butyl-5-(1-hydroxy-1-methylethyl)-4-methyl-1,3-thiazol-2(3H)-ylidene]-5-chloro-2-methoxybenzamide; and (5-chloro-N-[(2Z)-3-(cyclobutylmethyl)-5-(1-hydroxy-1-methylethyl)-4-methyl-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide; or a pharmaceutically acceptable salt thereof. |
| Claim: |
23. A pharmaceutical composition comprising therapeutically effective amount of a compound of claim 1 having formula (I) or a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier. |
| Claim: |
24. A method of treating neuropathic pain, nociceptive pain, and inflammatory pain in a mammal in need of such treatment comprising administering to the mammal a therapeutically effective amount of a compound of claim 1 having formula (I) or a pharmaceutically acceptable salt thereof. |
| Claim: |
25. A method of treating neuropathic pain, nociceptive pain, and inflammatory pain in a mammal in need of such treatment comprising administering to the mammal a therapeutically effective amount of a compound of claim 19 having formula (II) or a pharmaceutically acceptable salt thereof. |
| Current U.S. Class: |
514/371 |
| Current International Class: |
61; 07; 61 |
| رقم الانضمام: |
edspap.20100093814 |
| قاعدة البيانات: |
USPTO Patent Applications |