التفاصيل البيبلوغرافية
| العنوان: |
Methods for Modulating Tumor Growth and Metastasis |
| Document Number: |
20090258937 |
| تاريخ النشر: |
October 15, 2009 |
| Appl. No: |
12/266727 |
| Application Filed: |
November 07, 2008 |
| مستخلص: |
Methods and pharmaceutical compositions for modulating tumor growth or metastasis are provided. |
| Inventors: |
Lee, Francis Y. (Yardley, PA, US); Peck, Ronald (Cheshire, CT, US); Chaplin, David (Oxfordshire, GB); Pero, Ronald (Arlington, VT, US); Edvardsen, Klaus (Lund, SE) |
| Claim: |
1-60. (canceled) |
| Claim: |
61. A method for modulating tumor growth or metastasis in an animal in need thereof, comprising sequential or simultaneous administration of a taxane and a combretastatin compound in amounts effective therefore. |
| Claim: |
62. The method of claim 61, wherein said taxane is selected from the group consisting of paclitaxel and docetaxel. |
| Claim: |
63. The method of claim 61, wherein said combretastatin compound is a combretastatin A-4 compound. |
| Claim: |
64. The method of claim 63, wherein said combretastatin A-4 compound is combretastatin A-4 phosphate. |
| Claim: |
65. The method of claim 63, wherein said combretastatin A-4 phosphate is administered at least 3 hours prior to the taxane. |
| Claim: |
66. The method of claim 61, wherein said combretastatin compound is a combretastatin A-1 compound. |
| Claim: |
67. The method as claimed in claim 66, wherein said combretastatin A-1 compound is combretastatin A-1 phosphate. |
| Claim: |
68. The method as claimed in claim 66, wherein said combretastatin A-1 compound is combretastatin A-1 phosphate and said taxane is paclitaxel. |
| Claim: |
69. The method as claimed in claim 68, wherein said combretastatin A-1 phosphate is administered at least 3 hours prior to paclitaxel. |
| Claim: |
70. A method for modulating tumor growth or metastasis in an animal in need thereof, comprising administration of a combretastatin compound and a taxane, in amounts effective therefor, wherein said combretastatin compound is administered at a time relative to administration of said taxane sufficient to modulate blood flow to said tumor to provide a time-dependent effective tumor concentration of said taxane. |
| Claim: |
71. A pharmaceutical composition for modulating tumor growth or metastasis in an animal in need thereof, comprising a taxane and a combretastatin compound, in amounts effective therefore in a pharmaceutically acceptable carrier. |
| Claim: |
72. The pharmaceutical composition as claimed in claim 71, wherein said taxane is paclitaxel or docetaxel. |
| Claim: |
73. The pharmaceutical composition of claim 71, wherein said combretastatin compound is a combretastatin A-4 compound. |
| Claim: |
74. The pharmaceutical composition of claim 71, wherein said combretastatin compound is a combretastatin A-1 compound. |
| Current U.S. Class: |
514/449 |
| Current International Class: |
61; 61; 61 |
| رقم الانضمام: |
edspap.20090258937 |
| قاعدة البيانات: |
USPTO Patent Applications |