التفاصيل البيبلوغرافية
| العنوان: |
ALLERGY VACCINES |
| Document Number: |
20090191268 |
| تاريخ النشر: |
July 30, 2009 |
| Appl. No: |
12/327868 |
| Application Filed: |
December 04, 2008 |
| مستخلص: |
The invention provides methods and materials related to vaccines against self polypeptides. For example, the invention provides compositions containing chimeric IgE polypeptides and adjuvants. |
| Inventors: |
Hellman, Lars T. (Uppsala, SE); Persson, Stefan (Uppsala, SE); Jansson, Asa (Hagersten, SE) |
| Claim: |
1. A composition comprising a polypeptide and an aluminum compound, wherein said polypeptide comprises a self IgE polypeptide sequence, and wherein administration of said composition to a mammal reduces the level of detectable free IgE in said mammal. |
| Claim: |
2. The composition of claim 1, wherein said polypeptide is a chimeric IgE polypeptide. |
| Claim: |
3. The composition of claim 1, wherein said polypeptide comprises a sequence set forth in SEQ ID NO:3, SEQ ID NO:6, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, or SEQ ID NO:21. |
| Claim: |
4. The composition of claim 1, wherein said composition comprises between about ten micrograms and about one gram of said polypeptide. |
| Claim: |
5. The composition of claim 1, wherein said composition comprises about 3 to about 300 micrograms of said polypeptide. |
| Claim: |
6. The composition of claim 1, wherein said aluminum compound is an aluminum hydrogel compound. |
| Claim: |
7. The composition of claim 1, wherein said aluminum compound is alum. |
| Claim: |
8. The composition of claim 7, wherein said composition comprises between about ten microliters and about one milliliter of said alum. |
| Claim: |
9. The composition of claim 7, wherein said composition comprises about 50 microliters of said alum. |
| Claim: |
10. The composition of claim 1, wherein said reduction is at least about a 10 percent reduction. |
| Claim: |
11. The composition of claim 1, wherein said reduction is at least about a 30 percent reduction. |
| Claim: |
12. The composition of claim 1, wherein said reduction is a reduction from about 10 percent to about 95 percent. |
| Claim: |
13. The composition of claim 1, wherein said reduction is a reduction from about 20 percent to about 95 percent. |
| Claim: |
14. The composition of claim 1, wherein said reduction is detectable in an ELISA. |
| Claim: |
15. The composition of claim 14, wherein an IgE receptor polypeptide sequence is used in said ELISA. |
| Claim: |
16. The composition of claim 1, wherein said administration of said composition to said mammal produces an anti self IgE antibody response with a titer dilution50 value greater than 100. |
| Claim: |
17. The composition of claim 16, wherein said titer dilution50 value is greater than 200. |
| Claim: |
18. The composition of claim 16, wherein said titer dilution50 value is greater than 400. |
| Claim: |
19. A method for inducing an anti self IgE antibody response in a mammal, said method comprising administering to said mammal a composition under conditions wherein said mammal reduces the level of detectable free IgE in said mammal, wherein said composition comprises a polypeptide and an aluminum compound, and wherein said polypeptide comprises a self polypeptide sequence. |
| Claim: |
20. The method of claim 19, wherein said polypeptide comprises an amino acid sequence set forth in SEQ ID NO:3, SEQ ID NO:6, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, or SEQ ID NO:21. |
| Current U.S. Class: |
424/484 |
| Current International Class: |
61; 61 |
| رقم الانضمام: |
edspap.20090191268 |
| قاعدة البيانات: |
USPTO Patent Applications |